特異性

The mouse monoclonal antibody MHD4-46 recognizes the extracellular domain of DLL4 (δ-like ligand 4) antigen, a type I transmembrane protein which plays an important role in vascular development.

抗原情報

DLL4 (δ-like ligand 4) is one of five ligands of Notch receptors. It interacts with Notch1 and Notch4. DLL4 is up-regulated at sites of physiologic and pathologic angiogenesis, whereas its expression is low in most adult normal tissues. It is also highly expressed in human clear-cell renal carcinomas, bladder cancers, and breast cancers. Blocking the DLL4-Notch interaction seems to be a promising therapeutic approach.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Oishi H, Sunamura M, Egawa S, Motoi F, Unno M, Furukawa T, Habib NA, Yagita H: Blockade of delta‑like ligand 4 signaling inhibits both growth and angiogenesis of pancreatic cancer. Pancreas. 2010·Aug; 39(6):897‑903. <·PMID:·20182391·>
• Sekine C, Koyanagi A, Koyama N, Hozumi K, Chiba S, Yagita H: Differential regulation of osteoclastogenesis by Notch2/Delta‑like 1 and Notch1/Jagged1 axes. Arthritis·Res·Ther. 2012·Mar·5; 14(2):R45. <·PMID:·22390640·>
• Yamanda S, Ebihara S, Asada M, Okazaki T, Niu K, Ebihara T, Koyanagi A, Yamaguchi N, Yagita H, Arai H: Role of ephrinB2 in nonproductive angiogenesis induced by Delta‑like 4 blockade. Blood. 2009·Apr·9; 113(15):3631‑9. <·PMID:·19218547·>