CyFlow CD144 Purified
品番 | CP087269 | ||
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抗体名 | Anti-Hu CD144 PURI,55-7H1 | ||
包装単位 | 0.1 mg | ||
濃度 | 1 mg/ml | ||
容量 | 0.1 ml | ||
関連製品 (アイソタイプコントロール) |
Mouse IgG1 Purified (BJ561896) Mouse IgG1 Purified (AS224818) |
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反応性|交差吸着 | Human | レーザー | |
抗原 | CD144, VE-cadherin, 7B4 | 最大蛍光波長 | - |
クローン | 55-7H1 | 最大励起波長 | - |
ホスト | Mouse | 標識/Format | Purified |
アイソタイプ | IgG1 | 研究分野 | Immunophenotyping |
クローナリティ | monoclonal | 用途 | Flow cytometry |
Anti-Hu CD144 PURI,55-7H1
特異性
The mouse monoclonal antibody 55-7H1 recognizes a calcium-independent epitope on CD144 antigen, an adhesion molecule expressed on endothelial cells.
抗原情報
CD144 (VE-cadherin, cadherin 5) is the major cadherin that is present at endothelial junctions. It is also strictly endothelial specific. Under vascular permeability increasing conditions (and also in capillaries and veins) CD144 is being phosphorylated, which promotes its rapid and reversible internalization. On the contrary, binding of p120 catenin (δ1 catenin) maintains CD144 localization at the plasma membrane, which stabilizes the junction and reduces vascular permeability.
利用方法
保存方法
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
安定性情報
Do not use after expiration date stamped on vial label.
レファレンス
• Dejana E, Orsenigo F: Endothelial adherens junctions at a glance. J·Cell·Sci. 2013·Jun·15; 126(Pt 12):2545‑9. <·PMID:·23781019·>
• Limaye V, Li X, Hahn C, Xia P, Berndt MC, Vadas MA, Gamble JR: Sphingosine kinase‑1 enhances endothelial cell survival through a PECAM‑1‑dependent activation of PI‑3K/Akt and regulation of Bcl‑2 family members. Blood. 2005·Apr·15; 105(8):3169‑77. <·PMID:·15632208·>
• Hamilton RD, Foss AJ, Leach L: Establishment of a human in vitro model of the outer blood‑retinal barrier. J·Anat. 2007·Dec; 211(6):707‑16. <·PMID:·17922819·>
• De Ugarte DA, Alfonso Z, Zuk PA, Elbarbary A, Zhu M, Ashjian P, Benhaim P, Hedrick MH, Fraser JK: Differential expression of stem cell mobilization‑associated molecules on multi‑lineage cells from adipose tissue and bone marrow. Immunol·Lett. 2003·Oct·31; 89(2‑3):267‑70. <·PMID:·14556988·>
• Agrawal V, Kelly J, Tottey S, Daly KA, Johnson SA, Siu BF, Reing J, Badylak SF: An isolated cryptic peptide influences osteogenesis and bone remodeling in an adult mammalian model of digit amputation. Tissue·Eng·Part·A. 2011·Dec; 17(23‑24):3033‑44. <·PMID:·21740273·>
• Tisato V, Zauli G, Voltan R, Gianesini S, di Iasio MG, Volpi I, Fiorentini G, Zamboni P, Secchiero P: Endothelial cells obtained from patients affected by chronic venous disease exhibit a pro‑inflammatory phenotype. PLoS·One. 2012; 7(6): <·PMID:·22737245·>
Available Safety Data Sheets
CyFlow™ monoclonal antibodies SDS CA EN