CyFlow CD3 zeta Purified
品番 | CK521072 | ||
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抗体名 | Anti-Hu/Ms CD3 ZETA PURI,EM-26 | ||
包装単位 | 0.1 mg | ||
濃度 | 1 mg/ml | ||
容量 | 0.1 ml | ||
関連製品 (アイソタイプコントロール) |
Mouse IgG1 Purified (BJ561896) Mouse IgG1 Purified (AS224818) |
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反応性|交差吸着 | Human | Mouse | レーザー | |
抗原 | CD3 ζ (Phospho-Tyr72) | 最大蛍光波長 | - |
クローン | EM-26 | 最大励起波長 | - |
ホスト | Mouse | 標識/Format | Purified |
アイソタイプ | IgG1 | 研究分野 | Immunophenotyping |
クローナリティ | monoclonal | 用途 | Flow cytometry |
Anti-Hu/Ms CD3 ZETA PURI,EM-26
特異性
The mouse monoclonal antibody EM-26 recognizes phosphorylated tyrosine 72 of CD3 ζ chain (CD247), which is a component of TCR/CD3 complex expressed on T cells.
抗原情報
CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3γ, CD3 δ, CD3ε and CD3ζ. These CD3 subunits are structurally related members of the immunoglobulins superfamily encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.
利用方法
保存方法
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
安定性情報
Do not use after expiration date stamped on vial label.
レファレンス
• Borroto A, Arellano I, Dopfer EP, Prouza M, Suchanek M, Fuentes M, Orfao A, Schamel WW, Alarcón B: Nck recruitment to the TCR required for ZAP70 activation during thymic development. J·Immunol. 2013·Feb·1; 190(3):1103‑12. <·PMID:·23267019·>
• Dopfer EP, Schöpf B, Louis-Dit-Sully C, Dengler E, Höhne K, Klescová A, Prouza M, Suchanek M, Reth M, Schamel WW: Analysis of novel phospho‑ITAM specific antibodies in a S2 reconstitution system for TCR‑CD3 signalling. Immunol·Lett. 2010·May·4; 130(1‑2):43‑50. <·PMID:·20005895·>
Available Safety Data Sheets
CyFlow™ monoclonal antibodies SDS CA EN