特異性

The mouse monoclonal antibody 6-434 recognizes CD328 (Siglec-7) antigen, a 75 kDa transmembrane glycoprotein expressed mainly on NK cells, dendritic cells and monocytes.

抗原情報

CD328 (Siglec-7, p75/AIRM1) is a 75 kDa type I transmembrane glycoprotein of sialic acid-binding immunoglobulin-like lectin (Siglec) family. CD328 binds to sialylated glycans with α2,6 sialyl and α2,8 disyalyl residues and mediates sialic acid-dependent cell-cell binding. As it contains in its intracellular part the immunoreceptor tyrosine-based inhibitory motif (ITIM), it serves as an inhibitory receptor, e.g. of NK cells.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Zola H, Swart B, Banham A, Barry S, Beare A, Bensussan A, Boumsell L, D Buckley C, Buhring HJ, Clark G, Engel P, Fox D, Jin BQ, Macardle PJ, Malavasi F, Mason D, Stockinger H, Yang X: CD molecules 2006: human cell differentiation molecules. J·Immunol·Methods. 2007·Jan·30; 319(1‑2):1‑5. <·PMID:·17174972·>