CyFlow CD36 APC
| 品番 | CQ855808 | ||
|---|---|---|---|
| 抗体名 | Anti-Hu CD36 APC,TR9 | ||
| 包装単位 | 100 tests | ||
| 濃度 | - | ||
| 容量 | 1 ml | ||
| 関連製品 (アイソタイプコントロール) |
Mouse IgG1 APC (AB294043) |
||
| 反応性|交差吸着 | Human | レーザー | Red |
| 抗原 | CD36, GPIV, GP3B | 最大蛍光波長 | 660 nm |
| クローン | TR9 | 最大励起波長 | 650 nm |
| ホスト | Mouse | 標識/Format | APC |
| アイソタイプ | IgG1 | 研究分野 | Immunophenotyping |
| クローナリティ | monoclonal | 用途 | Flow cytometry |
Anti-Hu CD36 APC,TR9
特異性
The mouse monoclonal antibody TR9 recognizes CD36 antigen, a 85 kDa integral membrane glycoprotein expressed on platelets, macrophages, endothelial cells, early erythroid cells and megakaryocytes. The antibody TR9 cross-blocks binding of FITC-labeled standard antibody OKM5. Anti-CD36 antibodies inhibit adhesive functions (e.g. adherence of infected erythrocytes to target cells).
抗原情報
CD36 (FAT; fatty acid translocase) is an 85-113 kDa ditopic glycosylated protein that belongs to the class B family of scavenger receptors. CD36 is expressed by most resting marginal zone B cells but not by follicular and B1 B cells, and it is rapidly induced on Follicular B cells in vitro upon TLR and CD40 stimulation. CD36 does not affect the development of B cells, but modulates both primary and secondary antibody response. Similarly to glucose transporter GLUT4, CD36 is translocated from intracellular pools to the plasma membrane following cell stimulation by insulin. In mouse, CD36 is responsible for gustatory perception of long-chain fatty acids.
利用方法
The reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10 µl reagent / 100 µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
保存方法
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
安定性情報
Do not use after expiration date stamped on vial label.
レファレンス
• Gaillard D, Laugerette F, Darcel N, El-Yassimi A, Passilly-Degrace P, Hichami A, Akhtar Khan N, Montmayeur JP, Besnard P: The gustatory pathway is involved in CD36‑mediated orosensory perception of long‑chain fatty acids in the mouse. FASEB·J. 2008·May; 22(5):145‑68. <·PMID:·18162488·>
• van Oort MM, van Doorn JM, Bonen A, Glatz JF, van der Horst DJ, Rodenburg KW, Luiken JJ: Insulin‑induced translocation of CD36 to the plasma membrane is reversible and shows similarity to that of GLUT4. Biochim·Biophys·Acta. 2008·Jan-Feb; 1781(1‑2):61‑71. <·PMID:·18167317·>
• Won WJ, Bachmann MF, Kearney JF: CD36 Is Differentially Expressed on B Cell Subsets during Development and in Responses to Antigen. J·Immunol. 2008·Jan·1; 180(1):230‑7. <·PMID:·18097024·>
Available Safety Data Sheets
CyFlow™ monoclonal antibodies SDS CA EN