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CyFlow CD140b Purified

品番 BX650702
抗体名 Anti-Hu CD140B PURI,18A2
包装単位 0.1 mg
濃度 1 mg/ml
容量 0.1 ml
関連製品
(アイソタイプコントロール)
Mouse IgG1 Purified (BJ561896)
Mouse IgG1 Purified (AS224818)
反応性|交差吸着 Human レーザー
抗原 CD140b, PDGFRB, PDGRF1 最大蛍光波長 -
クローン 18A2 最大励起波長 -
ホスト Mouse 標識/Format Purified
アイソタイプ IgG1 研究分野 Immunophenotyping | Signaling
クローナリティ monoclonal 用途

Flow cytometry
Immunocytochemistry

Anti-Hu CD140B PURI,18A2

特異性

The monoclonal antibody 18A2 recognizes CD140b antigen, the 180-190 kDa β chain of platelet-derived growth factor receptor, which is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative roles.

抗原情報

CD140b (PDGF-RB; platelet-derived growth factor receptor β) is a cell surface receptor for members of platelet-derived growth factor family, whose intracellular part contains a tyrosine kinase domain. CD140b forms homodimers, or heterodimerizes with CD140a (PDGF-RA). Whereas CD140a can have both pro-proliferative or anti-proliferative effects, the CD140b induces in various cell types their proliferation and migration. CD140b has also developmental roles in the cardiovascular system and is preferentially expressed on some tumors such as medulloblastoma.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Andrae J, Gallini R, Betsholtz C: Role of platelet‑derived growth factors in physiology and medicine. Genes·Dev. 2008·May·15; 22(10):1276‑312. <·PMID:·18483217·>
• Faraone D, Aguzzi MS, Toietta G, Facchiano AM, Facchiano F, Magenta A, Martelli F, Truffa S, Cesareo E, Ribatti D, Capogrossi MC, Facchiano A: Platelet‑derived growth factor‑receptor alpha strongly inhibits melanoma growth in vitro and in vivo. Neoplasia. 2009·Aug; 11(8):732‑42. <·PMID:·19649203·>
• Fekete N, Rojewski MT, Fürst D, Kreja L, Ignatius A, Dausend J, Schrezenmeier H: GMP‑compliant isolation and large‑scale expansion of bone marrow‑derived MSC. PLoS·One. 2012; 7(8):e43255. <·PMID:·22905242·>
• French WJ, Creemers EE, Tallquist MD: Platelet‑derived growth factor receptors direct vascular development independent of vascular smooth muscle cell function. Mol·Cell·Biol. 2008·Sep; 28(18):5646‑57. <·PMID:·18606782·>
• Schmahl J, Rizzolo K, Soriano P: The PDGF signaling pathway controls multiple steroid‑producing lineages. Genes·Dev. 2008·Dec·1; 22(23):3255‑67. <·PMID:·19056881·>

Available Safety Data Sheets

CyFlow™ monoclonal antibodies SDS CA EN

Available Technical Data Sheets

CyFlow™ CD140b Purified (18A2) BX650702 TDS (US)