CyFlow CD59 Azide Free
品番 | BR267721 | ||
---|---|---|---|
抗体名 | Anti-Hu CD59 AZIDFREE,MEM-129 | ||
包装単位 | 0.1 mg | ||
濃度 | 1 mg/ml | ||
容量 | 0.1 ml | ||
関連製品 (アイソタイプコントロール) |
- | ||
反応性|交差吸着 | Human | Pig | レーザー | |
抗原 | CD59, Protectin H19 | 最大蛍光波長 | - |
クローン | MEM-129 | 最大励起波長 | - |
ホスト | Mouse | 標識/Format | Azide Free |
アイソタイプ | IgM | 研究分野 | Immunophenotyping |
クローナリティ | monoclonal | 用途 | Flow cytometry |
Anti-Hu CD59 AZIDFREE,MEM-129
特異性
The mouse monoclonal antibody MEM-129 recognizes CD59 antigen, a 18-20 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on all hematopoietic cells; it is widely present on cells in all tissues.
抗原情報
CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.
利用方法
保存方法
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
安定性情報
Do not use after expiration date stamped on vial label.
レファレンス
• Baalasubramanian S, Harris CL, Donev RM, Mizuno M, Omidvar N, Song WC, Morgan BP: CD59a is the primary regulator of membrane attack complex assembly in the mouse. J·Immunol. 2004·Sep·15; 173(6):3684‑92. <·PMID:·15356114·>
• Menu E, Tsai BC, Bothwell AL, Sims PJ, Bierer BE: CD59 costimulation of T cell activation: CD58 dependence and requirement for glycosylation. J·Immunol. 1994·Sep·15; 153(6):2444‑56. <·PMID:·7521361·>
• Meri S, Morgan BP, Davies A, Daniels RH, Olavesen MG, Waldmann H, Lachmann PJ: Human protectin (CD59), an 18,000‑20,000 MW complement lysis restricting factor, inhibits C5b‑8 catalysed insertion of C9 into lipid bilayers. Immunology. 1990·Sep; 71(1):42614. <·PMID:·2172297·>
• Olweus J, Lund-Johansen F, Terstappen LW: CD64/Fc gamma RI is a granulo‑monocytic lineage marker on CD34+ hematopoietic progenitor cells. Blood. 1995·May·1; 85(9):2402‑13. <·PMID:·7537112·>
• Rooney IA, Davies A, Griffiths D, Williams JD, Davies M, Meri S, Lachmann PJ, Morgan BP: The complement‑inhibiting protein, protectin (CD59 antigen), is present and functionally active on glomerular epithelial cells. Clin·Exp·Immunol. 1991·Feb; 83(2):251‑6. <·PMID:·1704296·>
• Stulnig TM, Berger M, Sigmund T, Stockinger H, Horejsí V, Waldhäusl W: Signal transduction via glycosyl phosphatidylinositol‑anchored proteins in T cells is inhibited by lowering cellular cholesterol. J·Biol·Chem. 1997·Aug·1; 272(31):19242‑7. <·PMID:·9235917·>
Available Safety Data Sheets
CyFlow™ monoclonal antibodies SDS CA EN