特異性

The mouse monoclonal antibody DR-4-02 recognizes CD261 (TRAIL-R1) antigen, a human death receptor 4 (468 amino acids) expressed in most human tissues (spleen, peripheral blood leukocytes, thymus) and in a variety of tumour-derived cell lines.

抗原情報

CD261 (TRAIL-R1; TRAIL receptor 1 or DR4) is a type I transmembrane protein. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF κB activation in many cells and tissues.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Corallini F, Milani D, Nicolin V, Secchiero P: TRAIL, caspases and maturation of normal and leukemic myeloid precursors. . Leuk·Lymphoma. 2006·Aug; 47(8):1459‑6. <·PMID:·16966254·>
• Simova S, Klima M, Cermak L, Sourkova V, Andera L: Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL‑R1/DR4 to the plasma membrane. Apoptosis. 2008·Mar; 13(3):423‑36. <·PMID:·18165900·>