CyFlow CD140a Biotin
| 品番 | AS196282 | ||
|---|---|---|---|
| 抗体名 | Anti-Hu CD140A BIOTIN,16A1 | ||
| 包装単位 | 0.1 mg | ||
| 濃度 | 1 mg/ml | ||
| 容量 | 0.1 ml | ||
| 関連製品 (アイソタイプコントロール) |
Mouse IgG1 Biotin (AQ807476) |
||
| 反応性|交差吸着 | Human | レーザー | |
| 抗原 | CD140a, PDGFRA, PDGRF2 | 最大蛍光波長 | - |
| クローン | 16A1 | 最大励起波長 | - |
| ホスト | Mouse | 標識/Format | Biotin |
| アイソタイプ | IgG1 | 研究分野 | Immunophenotyping | Signaling |
| クローナリティ | monoclonal | 用途 | Flow cytometry |
Anti-Hu CD140A BIOTIN,16A1
特異性
The mouse monoclonal antibody 16A1 recognizes CD140a antigen, the 170 kDa α chain of platelet-derived growth factor receptor, which is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative or anti-proliferative roles in various tumors.
抗原情報
CD140a (PDGF-RA; platelet-derived growth factor receptor α) is a cell surface receptor for members of platelet-derived growth factor family, whose intracellular part contains a tyrosine kinase domain. CD140a forms homodimers, or heterodimerizes with CD140b (PDGF-RB). Whereas CD140b induces in different cell types their proliferation and migration, the role of CD140a is more controversial, with pro-proliferative or anti-proliferative effects. CD140a has early developmental functions, mediates mesodermal cell migration, and later acts in signaling associated in epithelial-mesenchymal interactions.
利用方法
The reagent is designed for indirect immunofluorescence analysis by Flow Cytometry. Suggested working usage is 3 µg/ml. Indicated dilution is recommended starting point for use of this product, but working concentrations should be validated by the investigator.
保存方法
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
安定性情報
Do not use after expiration date stamped on vial label.
レファレンス
• Andrae J, Gallini R, Betsholtz C: Role of platelet‑derived growth factors in physiology and medicine. Genes·Dev. 2008·May·15; 22(10):1276‑312. <·PMID:·18483217·>
• Faraone D, Aguzzi MS, Toietta G, Facchiano AM, Facchiano F, Magenta A, Martelli F, Truffa S, Cesareo E, Ribatti D, Capogrossi MC, Facchiano A: Platelet‑derived growth factor‑receptor alpha strongly inhibits melanoma growth in vitro and in vivo. Neoplasia. 2009·Aug; 11(8):732‑42. <·PMID:·19649203·>
• French WJ, Creemers EE, Tallquist MD: Platelet‑derived growth factor receptors direct vascular development independent of vascular smooth muscle cell function. Mol·Cell·Biol. 2008·Sep; 28(18):5646‑57. <·PMID:·18606782·>
• Kish DD, Gorbachev AV, Fairchild RL: CD8+ T cells produce IL‑2, which is required for CD(4+)CD25+ T cell regulation of effector CD8+ T cell development for contact hypersensitivity responses. J·Leukoc·Biol. 2005·Sep; 78(3):725‑35. <·PMID:·16000396·>
• Schmahl J, Rizzolo K, Soriano P: The PDGF signaling pathway controls multiple steroid‑producing lineages. Genes·Dev. 2008·Dec·1; 22(23):3255‑67. <·PMID:·19056881·>
Available Safety Data Sheets
CyFlow™ monoclonal antibodies SDS CA EN