CyFlow CD42a Purified
品番 | AK114812 | ||
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抗体名 | Anti-Hu CD42A PURI,GR-P | ||
包装単位 | 0.1 mg | ||
濃度 | 1 mg/ml | ||
容量 | 0.1 ml | ||
関連製品 (アイソタイプコントロール) |
Mouse IgG1 Purified (BJ561896) Mouse IgG1 Purified (AS224818) |
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反応性|交差吸着 | Human | Dog | レーザー | |
抗原 | CD42a, GPIX | 最大蛍光波長 | - |
クローン | GR-P | 最大励起波長 | - |
ホスト | Mouse | 標識/Format | Purified |
アイソタイプ | IgG1 | 研究分野 | Immunophenotyping |
クローナリティ | monoclonal | 用途 | Flow cytometry |
Anti-Hu CD42A PURI,GR-P
特異性
The mouse monoclonal antibody GR-P (GRP-P) recognizes CD42a antigen, a 22 kDa transmembrane protein constitutively expressed on megakaryocytes and platelets.
抗原情報
CD42a (GPIX; Glycoprotein 9) composes together with GPIb α, GPIb β and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. Defects in the gene encoding CD42a are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency.
利用方法
保存方法
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
安定性情報
Do not use after expiration date stamped on vial label.
レファレンス
• Brown SB, Clarke MC, Magowan L, Sanderson H, Savill J: Constitutive death of platelets leading to scavenger receptor‑mediated phagocytosis: A caspase‑independent cell clearance program. J·Biol·Chem. 2000·Feb·25; 275(8):5987‑96. <·PMID:·10681593·>
• Din JN, Aftab SM, Jubb AW, Carnegy FH, Lyall K, Sarma J, Newby DE, Flapan AD: Effect of moderate walnut consumption on lipid profile, arterial stiffness and platelet activation in humans. Eur·J·Clin·Nutr. 2011·Feb; 65(2):234‑9. <·PMID:·21048773·>
• Harding SA, Din JN, Sarma J, Josephs DH, Fox KA, Newby DE: Promotion of proinflammatory interactions between platelets and monocytes by unfractionated heparin. Heart. 2006·Nov; 92(11):1635‑8. <·PMID:·16709700·>
• Vettore S, Scandellari R, Moro S, Lombardi AM, Scapin M, Randi ML, Fabris F: Novel point mutation in a leucine‑rich repeat of the GPIb alpha chain of the platelet von Willebrand factor receptor, GPIb/IX/V, resulting in an inherited dominant form of Bernard‑Soulier syndrome affecting two unrelated families: the N41H variant. Haematologica. 2008·Nov; 93(11):1743‑7. <·PMID:·18815197·>
• Knapp W, Dorken B, Gilks W, Rieber EP, Schmidt RE, Stein H, von dem Borne AEGK (Eds): Leucocyte Typing IV. Oxford·University·Press,·Oxford. 1989; 1‑1820. <·NLM·ID:·8914679·>
Available Safety Data Sheets
CyFlow™ monoclonal antibodies SDS CA EN