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CyFlow SIT Purified

品番 CZ912316
抗体名 Anti-Hu SIT PURI,SIT-01
包装単位 0.1 mg
濃度 1 mg/ml
容量 0.1 ml
関連製品
(アイソタイプコントロール)
-
反応性|交差吸着 Human レーザー
抗原 SIT 最大蛍光波長 -
クローン SIT-01 最大励起波長 -
ホスト Mouse 標識/Format Purified
アイソタイプ IgG1 研究分野 Adaptor proteins
クローナリティ monoclonal 用途

Flow cytometry
Immunoprecipitation
Western blot

Anti-Hu SIT PURI,SIT-01

特異性

The mouse monoclonal antibody SIT-01 recognizes SIT (SHP2-interacting transmembrane adaptor protein) expressed exclusively in lymphoid organs. It weakly crossreacts with mouse SIT.

抗原情報

SIT (SHP2-interacting transmembrane adaptor protein) is expressed exclusively in lymphoid organs and acts either as a positive or as a negative regulatory element in T cell activation and in T cell development. Binding to Grb2 plays a pivotal role in signal transduction. Hubener et al. (2001) determined that the SIT gene contains 5 exons and spans 1.8 kb of genomic DNA. The SIT promoter demonstrated strong transcriptional activity and potential binding sites for both ubiquitous and lymphoid-specific transcription factors.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Horejsí V, Zhang W, Schraven B: Transmembrane adaptor proteins: organizers of immunoreceptor signalling. Nat·Rev·Immunol. 2004·Aug; 4(8):603‑16. <·PMID:·15286727·>
• Hubener C, Mincheva A, Lichter P, Schraven B, Bruyns E: Complete sequence, genomic organization, and chromosomal localization of the human gene encoding the SHP2‑interacting transmembrane adaptor protein (SIT). Immunogenetics. 2001·May-Jun; 53(4):337‑41. <·PMID:·11491537·>
• Marie-Cardine A, Kirchgessner H, Bruyns E, Shevchenko A, Mann M, Autschbach F, Ratnofsky S, Meuer S, Schraven B: SHP2‑interacting transmembrane adaptor protein (SIT), a novel disulfide‑linked dimer regulating human T cell activation. J·Exp·Med. 1999·Apr·19; 189(8):1181‑94. <·PMID:·10209036·>
• Simeoni L, Posevitz V, Kolsch U, Meinert I, Bruyns E, Pfeffer K, Reinhold D, Schraven B: The transmembrane adapter protein SIT regulates thymic development and peripheral T‑cell functions. Mol·Cell·Biol. 2005·Sep; 25(17):7557‑68. <·PMID:·16107703·>
• Tedoldi S, Paterson JC, Hansmann ML, Natkunam Y, Rudiger T, Angelisova P, Du MQ, Roberton H, Roncador G, Sanchez L, Pozzobon M, Masir N, Barry R, Pileri S, Mason DY, Marafioti T, Horejsi V: Transmembrane adaptor molecules: a new category of lymphoid‑cell markers. Blood. 2006·Jan·1; 107(1):213‑21. <·PMID:·16160011·>

Available Safety Data Sheets

CyFlow™ monoclonal antibodies SDS CA EN

Available Technical Data Sheets

CyFlow™ SIT Purified (SIT-01) CZ912316 TDS (US)