特異性

The mouse monoclonal antibody CH2 recognizes Fc fragment of human immunoglobulin M (IgM).

抗原情報

Immunoglobulin M (IgM) is produced as a 900 kDa pentamer, which is an efficient complement binder. This antibody type is produced initially in the immune response and it is the first immunoglobulin class to be synthesized by a fetus or newborn. IgM antibodies do not cross the placenta. IgM concentration in blood is 0.12 g/l and its biological survival (plasma T1/2) is 5 days.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Balogh Z, Merétey K, Falus A, Bozsóky S: Serological abnormalities in juvenile chronic arthritis: a review of 46 cases. Ann·Rheum·Dis. 1980·Apr; 39(2):129‑34. <·PMID:·6966908·>
• Brinkmann V, Heusser CH: T cell‑dependent differentiation of human B cells into IgM, IgG, IgA, or IgE plasma cells: high rate of antibody production by IgE plasma cells, but limited clonal expansion of IgE precursors. Cell·Immunol. 1993·Dec; 152(2):323‑32. <·PMID:·8258141·>
• Franklin EC: Structure and function of immunoglobulins. Acta·Endocrinol·Suppl·(Copenh). 1975; 194:77‑95. <·PMID:·47690·>
• Fuller JM, Keyser JW: Serum immunoglobulins after surgical operation. Clin·Chem. 1975·May; 21(6):667‑71. <·PMID:·1122610·>