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CyFlow CD41 Pacific Blue

品番 CX190753
抗体名 Anti-Hu CD41 PAC BLUE,MEM-06
包装単位 100 tests
濃度 -
容量 0.4 ml
関連製品
(アイソタイプコントロール)
Mouse IgG1 Pacific Blue™ (AP887259)
反応性|交差吸着 Human レーザー Violet
抗原 CD41, gpIIb 最大蛍光波長 455 nm
クローン MEM-06 最大励起波長 400 to 410 nm
ホスト Mouse 標識/Format Pacific Blue™
アイソタイプ IgG1 研究分野 Immunophenotyping
クローナリティ monoclonal 用途

Flow cytometry

Anti-Hu CD41 PAC BLUE,MEM-06

特異性

The mouse monoclonal antibody MEM-06 recognizes CD41 antigen, a transmembrane glycoprotein (integrin family) composed of two chains GPIIb α (heavy chain; 120 kDa) and GPIIb β (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.

抗原情報

CD41 (GPIIb; platelet glycoprotein IIb) is composed of two subunits (120 kDa GPIIb α and 23 kDa GPIIb β) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.

利用方法

The reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 4 µl reagent / 100 µl of whole blood or 10^6 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Debili N, Robin C, Schiavon V, Letestu R, Pflumio F, Mitjavila-Garcia MT, Coulombel L, Vainchenker W: Different expression of CD41 on human lymphoid and myeloid progenitors from adults and neonates. Blood. 2001·Apr·1; 97(7):2023‑30. <·PMID:·11264167·>
• Ferkowicz MJ, Starr M, Xie X, Li W, Johnson SA, Shelley WC, Morrison PR, Yoder MC: CD41 expression defines the onset of primitive and definitive hematopoiesis inthe murine embryo. Development. 2003·Sep; 130(18):4393‑403. <·PMID:·12900455·>
• Mitjavila-Garcia MT, Cailleret M, Godin I, Nogueira MM, Cohen-Solal K, Schiavon V, Lecluse Y, Le Pesteur F, Lagrue AH, Vainchenker W: Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells. Development. 2002·Apr; 129(8):2003‑13. <·PMID:·11934866·>
• Zhang J, Varas F, Stadtfeld M, Heck S, Faust N, Graf T: CD41‑YFP mice allow in vivo labeling of megakaryocytic cells and reveal a subset of platelets hyperreactive to thrombin stimulation. Exp·Hematol. 2007·Mar; 35(3):490‑499. <·PMID:·17309829·>