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CyFlow AGPS Purified

品番 CU923196
抗体名 Anti-Hu AGPS PURI,AGPS-03
包装単位 0.1 mg
濃度 1 mg/ml
容量 0.1 ml
関連製品
(アイソタイプコントロール)
Mouse IgG2a Purified (CJ747338)
Mouse IgG2a Purified (AP005692)
反応性|交差吸着 Human レーザー
抗原 AGPS 最大蛍光波長 -
クローン AGPS-03 最大励起波長 -
ホスト Mouse 標識/Format Purified
アイソタイプ IgG2a 研究分野 Others
クローナリティ monoclonal 用途

Flow cytometry
Western blot

Anti-Hu AGPS PURI,AGPS-03

特異性

The mouse monoclonal antibody AGPS-03 recognizes AGPS (alkykglycerone phosphate synthase) antigen, an peroxisomal enzyme important for lipid biosynthesis.

抗原情報

AGPS (alkylglycerone phosphate synthase) is an enzyme that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetone phosphate (acyl-DHAP) is converted to alkyl-DHAP by addition of a long chain alcohol and removal of a long-chain acid anion. The protein is localized to the inner side of the peroxisomal membrane and requires FAD as a cofactor. Mutations in AGPS gene have been associated with type 3 of rhizomelic chondrodysplasia punctata (RCDP3), and Zellweger syndrome. Higher expression of AGPS was observed in BCR/ABL positive leukemias and it was also described to be associated with higher risk of relapse.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Bhojwani D, Kang H, Menezes RX, Yang W, Sather H, Moskowitz NP, Min DJ, Potter JW, Harvey R, Hunger SP, Seibel N, Raetz EA, Pieters R, Horstmann MA, Relling MV, den Boer ML, Willman CL, Carroll WL: Gene expression signatures predictive of early response and outcome in high‑risk childhood acute lymphoblastic leukemia: A Children's Oncology Group Study. J·Clin·Oncol. 2008·Sep·20; 26(27):4376‑84. <·PMID:·18802149·>
• Grimm MO, Kuchenbecker J, Rothhaar TL, Grösgen S, Hundsdörfer B, Burg VK, Friess P, Müller U, Grimm HS, Riemenschneider M, Hartmann T: Plasmalogen synthesis is regulated via alkyl‑dihydroxyacetonephosphate‑synthase by amyloid precursor protein processing and is affected in Alzheimer'sdisease. J·Neurochem. 2011·Mar; 116(5):916‑25. <·PMID:·21214572·>
• Itzkovitz B, Jiralerspong S, Nimmo G, Loscalzo M, Horovitz DD, Snowden A, Moser A, Steinberg S, Braverman N: Functional characterization of novel mutations in GNPAT and AGPS, causing rhizomelic chondrodysplasia punctata (RCDP) types 2 and 3. Hum·Mutat. 2012·Jan; 33(1):189‑97. <·PMID:·21990100·>
• Yeoh EJ, Ross ME, Shurtleff SA, Williams WK, Patel D, Mahfouz R, Behm FG, Raimondi SC, Relling MV, Patel A, Cheng C, Campana D, Wilkins D, Zhou X, Li J, Liu H, Pui CH, Evans WE, Naeve C, Wong L, Downing JR: Classification, subtype discovery, and prediction of outcome in pediatric acutelymphoblastic leukemia by gene expression profiling. Cancer·Cell. 2002·Mar; 1(2):133‑43. <·PMID:·12086872·>

Available Safety Data Sheets

CyFlow™ monoclonal antibodies SDS CA EN

Available Technical Data Sheets

CyFlow™ AGPS Purified (AGPS-03) CU923196 TDS (US)