特異性

The mouse monoclonal antibody OPAL1-01 recognizes OPAL1 (outcome predictor in acute leukemia 1) antigen, a transmembrane adaptor protein expressed mainly by megacaryocytes and platelets.

抗原情報

OPAL1 (outcome predictor in acute leukemia 1) is an almost uncharacterized transmembrane adaptor protein expressed mainly by megacaryocytes and platelets. Its expression is enhanced on TEL/AML leukemic cells. The function of OPAL1 is unknown, although the presence of a cytochrome c-like heme-binding site and a transmembrane domain suggested OPAL1 may be involved in the mitochondrial electron transport chain. Its originally reported prognostic impact appears to be treatment dependent.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Holleman A, den Boer ML, Cheok MH, Kazemier KM, Pei D, Downing JR, Janka-Schaub GE, Göbel U, Graubner UB, Pui CH, Evans WE, Pieters R: Expression of the outcome predictor in acute leukemia 1 (OPAL1 gene is not an independent prognostic factor in patients treated according to COALL or St Jude protocols. Blood. 2006·Sep·15; 108(6):1984‑90. <·PMID:·16709928·>