CyFlow CD107b APC
| 品番 | CT778572 | ||
|---|---|---|---|
| 抗体名 | Anti-Hu CD107B APC,H4B4 | ||
| 包装単位 | 100 tests | ||
| 濃度 | - | ||
| 容量 | 1 ml | ||
| 関連製品 (アイソタイプコントロール) |
Mouse IgG1 APC (AB294043) |
||
| 反応性|交差吸着 | Human | レーザー | Red |
| 抗原 | CD107b, LAMP-2 | 最大蛍光波長 | 660 nm |
| クローン | H4B4 | 最大励起波長 | 650 nm |
| ホスト | Mouse | 標識/Format | APC |
| アイソタイプ | IgG1 | 研究分野 | Immunophenotyping |
| クローナリティ | monoclonal | 用途 | Flow cytometry |
Anti-Hu CD107B APC,H4B4
特異性
The mouse monoclonal antibody H4B4 recognizes CD107b antigen, an extensively glycosylated 100-120 kDa widely expressed lysosome-associated protein.
抗原情報
CD107b (LAMP-2; lysosome-associated membrane protein-2), together with CD107a (LAMP-1), is a major constituent of lysosomal membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes, especially CD107b is important regulator in successful phagosomal maturation. CD107b deficiency causes an accumulation of autophagosomes in many tissues leading to cardiomyopathy and myopathy (Danons disease). Immature CD107b is an approximately 45 kDa protein, but after extensive glycosylation the mature glycoprotein has about 100-120 kDa.
利用方法
The reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10 µl reagent / 100 µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
保存方法
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
安定性情報
Do not use after expiration date stamped on vial label.
レファレンス
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• Palmer DR, Fernandez S, Bisbing J, Peachman KK, Rao M, Barvir D, Gunther V, Burgess T, Kohno Y, Padmanabhan R, Sun W: Restricted replication and lysosomal trafficking of yellow fever 17D vaccine virus in human dendritic cells. J·Gen·Virol. 2007·Jan; 88(1):148‑56. <·PMID:·17170447·>
• Thedrez A, Harly C, Morice A, Salot S, Bonneville M, Scotet E: IL‑21‑mediated potentiation of antitumor cytolytic and proinflammatory responses of human V gamma 9V delta 2 T cells for adoptive immunotherapy. J·Immunol. 2009·Mar·15; 182(6):3423‑31. <·PMID:·19265120·>
Available Safety Data Sheets
CyFlow™ monoclonal antibodies SDS CA EN