特異性

The mouse monoclonal antibody C-04 recognizes Cytokeratin 18, a 45 kDa member of intermediate filaments subfamily represented in epithelial tissues.

抗原情報

Cytokeratins are a subfamily of intermediate filaments and characterized by remarkable biochemical diversity. Cytokeratins are represented in epithelial tissues by at least 20 different polypeptides, molecular weight between 40 kDa and 68 kDa. The individual cytokeratin polypeptides are designated 1 to 20 and divided into the type I (acidic cytokeratins 9-20) and type II (basic to neutral cytokeratins 1-8) families. Cytokeratin 18 belongs to type I family (acidic cytokeratins).

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Bartek J, Vojtesek B, Staskova Z, Bartkova J, Kerekes Z, Rejthar A, Kovarik J: A series of 14 new monoclonal antibodies to keratins: characterization and value in diagnostic histopathology. J·Pathol. 1991·Jul; 164(3):215‑24. <·PMID:·1716305·>
• Cap J, Cerman J, Nemecek S, Marekova M, Hana V, Frysak Z: The influence of treatment with somatostatin analogues on morphology, proliferative and apoptotic activity in GH‑secreting pituitary adenomas. J·Clin·Neurosci. 2003·Jul; 10(4):444‑8. <·PMID:·12852883·>
• Kovarik J, et al: J·Tumor·Marker·Oncol. 1990; 5:219. <·No·PMID·>
• Kovarik J, Rejthar A, Lauerova L, Vojtesek B, Bartkova J: Monoclonal antibodies against individual cytokeratins in the detection of metastatic spread. Int·J·Cancer·Suppl. 1988; 3:50‑5. <·PMID:·2463228·>
• Lauerova L, Kovarik J, Bartek J, Rejthar A, Vojtesek B: Novel monoclonal antibodies defining epitope of human cytokeratin 18 molecule. Hybridoma. 1988·Oct; 7(5):495‑504. <·PMID:·2461901·>
• Taylor-Papadimitriou J, Stampfer M, Bartek J, Lewis A, Boshell M, Lane EB, Leigh IM: Keratin expression in human mammary epithelial cells cultured from normal and malignant tissue: relation to in vivo phenotypes and influence of medium. J·Cell·Sci. 1989·Nov; 94 ( 3):403‑13. <·PMID:·2483723·>
• Vojtĕsek B, Stasková Z, Nenutil R, Lauerová L, Kovarík J, Rejthar A, Bártková J, Bártek J: Monoclonal antibodies recognizing different epitopes of cytokeratin No.18. Folia·Biol·(Praha). 1989; 35(6):373‑82. <·PMID:·2483834·>