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CyFlow CD169 Purified

品番 CR476461
抗体名 Anti-Hu CD169 PURI,7-239
包装単位 0.1 mg
濃度 1 mg/ml
容量 0.1 ml
関連製品
(アイソタイプコントロール)
Mouse IgG1 Purified (BJ561896)
Mouse IgG1 Purified (AS224818)
反応性|交差吸着 Human レーザー
抗原 CD169, SIGLEC-1, SN 最大蛍光波長 -
クローン 7-239 最大励起波長 -
ホスト Mouse 標識/Format Purified
アイソタイプ IgG1 研究分野 Immunophenotyping
クローナリティ monoclonal 用途

Flow cytometry
Immunoprecipitation
Western blot
Immunohistochemistry (frozen sections)
Functional assays

Anti-Hu CD169 PURI,7-239

特異性

The mouse monoclonal antibody 7-239 recognizes CD169 antigen, a 210 kDa type I transmembrane glycoprotein expressed on macrophages and dendritic cells.

抗原情報

CD169 (Siglec-1 or sialoadhesin) is a type I transmembrane glycoprotein of the sialic acid binding Ig-like lectin family. It binds to sialylated glycoproteins on various haematopoietic cells to mediate cell-cell interactions. CD169 is expressed on a subset of macrophages and dendritic cells. On CD14+ monocytes its expression can be induced by interferon α and γ. High expression of CD169 is observed in the spleen, lymph nodes, bone marrow, and under inflammatory conditions rheumatoid arthritis and atherosclerosis, lower in the liver, lungs and gut. It has been shown to be involved in antigen presentation to invariant NKT cells, which play an important role in the innate arm of the immune system to modulate the subsequent acquired immune responses.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Kawasaki N, Vela JL, Nycholat CM, Rademacher C, Khurana A, van Rooijen N, Crocker PR, Kronenberg M, Paulson JC: Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation. Proc·Natl·Acad·Sci·USA. 2013·May·7; 110(19):7826‑31. <·PMID:·23610394·>
• Schrauf C, Kirchberger S, Majdic O, Seyerl M, Zlabinger GJ, Stuhlmeier KM, Sachet M, Seipelt J, Stöckl J: The ssRNA genome of human rhinovirus induces a type I IFN response but fails to induce maturation in human monocyte‑derived dendritic cells. J·Immunol. 2009·Oct·1; 183(7):4440‑8. <·PMID:·19734213·>

Available Safety Data Sheets

CyFlow™ monoclonal antibodies SDS CA EN

Available Technical Data Sheets

CyFlow™ CD169 Purified (7-239) CR476461 TDS (US)