特異性

The mouse monoclonal antibody B2M-01 recognizes β2-microglobulin associated with cell-surface MHC Class I molecules and other membrane antigens as well as with soluble β2-microglobulin. β2-microglobulin is a 12 kDa Ig like glycoprotein expressed on lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells and epithelial cells. It is absent on erythrocytes.

抗原情報

β2-microglobulin (β2M) non-covalently associates with the 44 kDa α chain to forms the HLA Class I antigen complex. Human β2-microglobulin associated with HLA Class I antigens is expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells. It is absent on erythrocytes.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Hilgert I, Horejsi V, Kristofova H: The use of murine monoclonal antibody B2M‑01 for detection and purification of human beta 2‑microglobulin. Folia·Biol·(Praha). 1984; 30(6):369‑76. <·PMID:·6394369·>
• Khurana M, Traum AZ, Aivado M, Wells MP, Guerrero M, Grall F, Libermann TA, Schachter AD: Urine proteomic profiling of pediatric nephrotic syndrome. Pediatr·Nephrol. 2006·Sep; 21(9):1257‑65. <·PMID:·16810512·>
• Lafon M, Prehaud C, Megret F, Lafage M, Mouillot G, Roa M, Moreau P, Rouas-Freiss N, Carosella ED: Modulation of HLA‑G Expression in Human Neural Cells after Neurotropic Viral Infections. J·Virol. 2005·Dec; 79(24):15226‑15237. <·PMID:·16306594·>
• Poláková K, Železníková T, Russ G: HLA‑G5 in the blood of leukemia patients and healthy individuals. Leuk·Res. 2013·Feb; 37(2):139‑45. <·PMID:·23146557·>