CyFlow CD120a Low Endotoxin
|抗体名||Anti-Hu CD120A LOW END,H398|
| Mouse IgG2a Low Endotoxin (AN242943)
|抗原||CD120a, TNFR1, TNFRSF1A||最大蛍光波長||-|
|アイソタイプ||IgG2a||研究分野||Immunophenotyping | Signaling|
Anti-Hu CD120A LOW END,H398
The mouse monoclonal antibody H398 recognizes the extracellular domain of CD120a antigen, a 55 kDa receptor for tumor necrosis factor. The antibody blocks biological activity of both natural and recombinant human TNF-α and TNF-β.
CD120a (TNF R1,TNFR55 or TNFRSF1A) is a 55 kDa receptor for tumor necrosis factor α and it is expressed in most tissues. By binding its trimeric ligand the CD120a protein forms trimers and the conformation change leads to dissociation of the inhibitory factor SODD from its intracellular death domain and in formation of signaling platform. CD120a can mediate apoptosis, and function as a regulator of inflammation. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
Do not use after expiration date stamped on vial label.
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