特異性

The mouse monoclonal antibody H398 recognizes the extracellular domain of CD120a antigen, a 55 kDa receptor for tumor necrosis factor. The antibody blocks biological activity of both natural and recombinant human TNF-α and TNF-β.

抗原情報

CD120a (TNF R1,TNFR55 or TNFRSF1A) is a 55 kDa receptor for tumor necrosis factor α and it is expressed in most tissues. By binding its trimeric ligand the CD120a protein forms trimers and the conformation change leads to dissociation of the inhibitory factor SODD from its intracellular death domain and in formation of signaling platform. CD120a can mediate apoptosis, and function as a regulator of inflammation. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Baker PK, Pettitt AR, Slupsky JR, Chen HJ, Glenn MA, Zuzel M, Cawley JC: Response of hairy cells to IFN‑alpha involves induction of apoptosis through autocrine TNF‑alpha and protection by adhesion. Blood. 2002·Jul·15; 100(2):647‑53. <·PMID:·12091360·>
• Buckley CD1, Ross EA, McGettrick HM, Osborne CE, Haworth O, Schmutz C, Stone PC, Salmon M, Matharu NM, Vohra RK, Nash GB, Rainger GE: Identification of a phenotypically and functionally distinct population of long‑lived neutrophils in a model of reverse endothelial migration. J·LeukocBiol. 2006·Feb; 79(2):303‑11. <·PMID:·16330528·>
• Kohrgruber N1, Halanek N, Gröger M, Winter D, Rappersberger K, Schmitt-Egenolf M, Stingl G, Maurer D: Survival, maturation, and function of CD11c‑ and CD11c+ peripheral blood dendritic cells are differentially regulated by cytokines. J·Immunol. 1999·Sep·15; 163(6):3250‑9. <·PMID:·10477594·>