特異性

The rat monoclonal antibody 4B12 recognizes mouse CD197 receptor, a 43 kDa G-protein-coupled receptor for chemokines CCL19 and CCL21.

抗原情報

CD197 (CCR7; chemokine receptor 7) is a seven membrane-spanning protein serving as a receptor for chemokines CCL19 and CCL21. It is expressed on most naive T cells, some hematopoietic stem cells, mature dendritic cells, NK cells and some memory T cells and B cells subsets. CD197 plays important roles in development of thymocytes, and regulating the recirculation and homing of lymphocytes and dendritic cells to secondary lymphoid organs.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Adachi K, Osada Y, Nakamura R, Tamada K, Hamano S: Unique T Cells with Unconventional Cytokine Profiles Induced in the Livers of Mice during Schistosoma mansoni Infection. PLoS·One. 2013·Dec·16; 8(12):e82698. <·PMID:·24358216·>
• Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA: NLRP10 is a NOD‑like receptor essential to initiate adaptive immunity by dendritic cells. Nature. 2012·Apr·25; 484(7395):510‑3. <·PMID:·22538615·>
• Huggins A, Paschalidis N, Flower RJ, Perretti M, D'Acquisto F: Annexin‑1‑deficient dendritic cells acquire a mature phenotype during differentiation. FASEB·J. 2009·Apr; 23(4):985‑96. <·PMID:·19029200·>
• Singh V, Gowthaman U, Jain S, Parihar P, Banskar S, Gupta P, Gupta UD, Agrewala JN: Coadministration of interleukins 7 and 15 with bacille Calmette‑Guérin mounts enduring T cell memory response against Mycobacterium tuberculosis. J·Infect·Dis. 2010·Aug·15; 202(3):480‑9. <·PMID:·20569158·>