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CyFlow CD123 Purified

品番 CL344110
抗体名 Anti-Hu CD123 PURI,6H6
包装単位 0.1 mg
濃度 1 mg/ml
容量 0.1 ml
関連製品
(アイソタイプコントロール)
Mouse IgG1 Purified (BJ561896)
Mouse IgG1 Purified (AS224818)
反応性|交差吸着 Human レーザー
抗原 CD123, IL-3Ra, IL3R 最大蛍光波長 -
クローン 6H6 最大励起波長 -
ホスト Mouse 標識/Format Purified
アイソタイプ IgG1 研究分野 Immunophenotyping | Signaling
クローナリティ monoclonal 用途

Flow cytometry
Immunoprecipitation
Western blot
Immunohistochemistry (frozen sections)

Anti-Hu CD123 PURI,6H6

特異性

The mouse monoclonal antibody 6H6 recognizes CD123 antigen, a 60-70 kDa transmembrane protein expressed by myeloid precursors, megakaryocytes, macrophages, dendritic cells, mast cells, basophils, and some B cells. This antibody does not inhibit IL-3 binding to its receptor.

抗原情報

CD123 is the α chain of interleukin 3 receptor (IL-3R α). This subunit heterodimerizes with the interleukin 3 receptor β chain (CD131), which is shared with other receptors. CD123 interacts with IL-3 specifically, but with low affinity, and association with the β subunit confers high affinity binding to the receptor heterodimer. Both chains are required for signaling, but receptor activation and signal transduction depend on IL-3 binding to CD123 as the initial step.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Herling M, Teitell MA, Shen RR, Medeiros LJ, Jones D: TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin. Blood. 2003·Jun·15; 101(12):5007‑9. <·PMID:·12576313·>
• Martín-Gayo E, Sierra-Filardi E, Corbí AL, Toribio ML: Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development. Blood. 2010·Jul·1; 115(26):5366‑75. <·PMID:·20357241·>
• Sun Q, Woodcock JM, Rapoport A, Stomski FC, Korpelainen EI, Bagley CJ, Goodall GJ, Smith WB, Gamble JR, Vadas MA, Lopez AF: Monoclonal antibody 7G3 recognizes the N‑terminal domain of the human interleukin‑3 (IL‑3) receptor alpha‑chain and functions as a specific IL‑3 receptor antagonist. Blood. 1996·Jan·1; 87(1):83‑92. <·PMID:·8547680·>

Available Safety Data Sheets

CyFlow™ monoclonal antibodies SDS CA EN

Available Technical Data Sheets

CyFlow™ CD123 Purified (6H6) CL344110 TDS (US)