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CyFlow CD18 Purified

品番 CK708893
抗体名 Anti-Ms CD18 PURI,M18/2
包装単位 0.1 mg
濃度 1 mg/ml
容量 0.1 ml
関連製品
(アイソタイプコントロール)
-
反応性|交差吸着 Mouse レーザー
抗原 CD18, b2 integrin 最大蛍光波長 -
クローン M18/2 最大励起波長 -
ホスト Rat 標識/Format Purified
アイソタイプ IgG2a 研究分野 Immunophenotyping | MHC
クローナリティ monoclonal 用途

Flow cytometry
Immunoprecipitation
Western blot
Immunohistochemistry
Functional assays

Anti-Ms CD18 PURI,M18/2

特異性

The rat monoclonal antibody M18/2 recognizes mouse CD18 antigen, a 95 kDa type I transmembrane protein expressed on all leukocytes.

抗原情報

CD18 (integrin β2 subunit) forms heterodimers with four types of CD11 molecule to constitute leukocyte (β2) integrins: αLβ2 (CD11a/CD18, LFA-1), αMβ2 (CD11b/CD18, Mac-1, CR3), αXβ2 (CD11c/CD18) and αDβ2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

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• Avni O, Pur Z, Yefenof E, Baniyash M: Complement receptor 3 of macrophages is associated with galectin‑1‑like protein. J·Immunol. 1998·Jun·15; 160(12):6151‑8. <·PMID:·9637533·>
• Barlow SC, Langston W, Matthews KM, Chidlow JH Jr, Kevil CG: CD18 deficiency protects against multiple low‑dose streptozotocin‑induced diabetes. Am·J·Pathol. 2004·Dec; 165(6):1849‑52. <·PMID:·15579429·>
• Cullere X, Lauterbach M, Tsuboi N, Mayadas TN: Neutrophil‑selective CD18 silencing using RNA interference in vivo. Blood. 2008·Apr·1; 111(7):3591‑8. <·PMID:·18216298·>
• Sakurai E, Taguchi H, Anand A, Ambati BK, Gragoudas ES, Miller JW, Adamis AP, Ambati J: Targeted disruption of the CD18 or ICAM‑1 gene inhibits choroidal neovascularization. Invest·Ophthalmol·Vis·Sci. 2003·Jun; 44(6):2743‑9. <·PMID:·12766082·>
• Sanchez-Madrid F, Simon P, Thompson S, Springer TA: Mapping of antigenic and functional epitopes on the alpha‑ and beta‑subunits of two related mouse glycoproteins involved in cell interactions, LFA‑1 and Mac‑1. J·Exp·Med. 1983·Aug·1; 158(2):586‑602. <·PMID:·6193226·>
• Varga G, Balkow S, Wild MK, Stadtbaeumer A, Krummen M, Rothoeft T, Higuchi T, Beissert S, Wethmar K, Scharffetter-Kochanek K, Vestweber D, Grabbe S: Active MAC‑1 (CD11b/CD18) on DCs inhibits full T‑cell activation. Blood. 2007·Jan·15; 109(2):661‑9. <·PMID:·17003381·>
• Watts GM, Beurskens FJ, Martin-Padura I, Ballantyne CM, Klickstein LB, Brenner MB, Lee DM: Manifestations of inflammatory arthritis are critically dependent on LFA‑1. J·Immunol. 2005·Mar·15; 174(6):3668‑75. <·PMID:·15749905·>
• Zahalka MA, Naor D: Beta 2‑integrin dependent aggregate formation between LB T cell lymphoma and spleen cells: assessment of correlation with spleen invasiveness. Int·Immunol. 1994·Jun; 6(6):917‑24. <·PMID:·7522049·>
• Zahalka MA, Okon E, Naor D: Blocking lymphoma invasiveness with a monoclonal antibody directed against the beta‑chain of the leukocyte adhesion molecule (CD18). J·Immunol. 1993·May·15; 150(10):4466‑77. <·PMID:·8097756·>