CyFlow CD11a Low Endotoxin
品番 | CH435905 | ||
---|---|---|---|
抗体名 | Anti-Ms CD11A LOW END,M17/4 | ||
包装単位 | 0.1 mg | ||
濃度 | 1 mg/ml | ||
容量 | 0.1 ml | ||
関連製品 (アイソタイプコントロール) |
- | ||
反応性|交差吸着 | Mouse | レーザー | |
抗原 | CD11a, LFA-1 | 最大蛍光波長 | - |
クローン | M17/4 | 最大励起波長 | - |
ホスト | Rat | 標識/Format | Low Endotoxin |
アイソタイプ | IgG2a | 研究分野 | Immunophenotyping | MHC |
クローナリティ | monoclonal | 用途 | Flow cytometry |
Anti-Ms CD11A LOW END,M17/4
特異性
The rat monoclonal antibody M17/4 recognizes mouse CD11a (α-subunit of murine LFA-1) antigen, a 180 kDa type I transmembrane glycoprotein expressed on B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils.
抗原情報
CD11a (LFA-1 α) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the αβ2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions.
利用方法
保存方法
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
安定性情報
Do not use after expiration date stamped on vial label.
レファレンス
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• Bellingan GJ, Xu P, Cooksley H, Cauldwell H, Shock A, Bottoms S, Haslett C, Mutsaers SE, Laurent GJ: Adhesion molecule‑dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation. J·Exp·Med. 2002·Dec·2; 196(11):1515‑21. <·PMID:·12461086·>
• Beyer M, Wang H, Peters N, Doths S, Koerner-Rettberg C, Openshaw PJ, Schwarze J: The beta2 integrin CD11c distinguishes a subset of cytotoxic pulmonary T cells with potent antiviral effects in vitro and in vivo. Respir·Res. 2005·Jul·12; 6:70. <·PMID:·16011799·>
• Koseki S, Miura S, Fujimori H, Hokari R, Komoto S, Hara Y, Ogino T, Nagata H, Goto M, Hachimura S, Kaminogawa S, Ishii H: In situ demonstration of intraepithelial lymphocyte adhesion to villus microvessels of the small intestine. Int·Immunol. 2001·Sep; 13(9):1165‑74. <·PMID:·11526097·>
• Kuhlman P, Moy VT, Lollo BA, Brian AA: The accessory function of murine intercellular adhesion molecule‑1 in T lymphocyte activation: Contributions of adhesion and co‑activation. J·Immunol. 1991·Mar·15; 146(6):1773‑82. <·PMID:·1672331·>
• Papayannopoulou T, Priestley GV, Nakamoto B, Zafiropoulos V, Scott LM, Harlan JM: Synergistic mobilization of hemopoietic progenitor cells using concurrent beta1 and beta2 integrin blockade or beta2‑deficient mice. Blood. 2001·Mar·1; 97(5):1282‑8. <·PMID:·11222371·>
• Sanchez-Madrid F, Davignon D, Martz E, Springer TA: Antigens involved in mouse cytolytic T‑lymphocyte (CTL)‑mediated killing: functional screening and topographic relationship. Cell·Immunol. 1982·Oct; 73(1):1-11. <·PMID:·6983917·>
• Smith SS, Barnum SR: Differential expression of beta 2‑integrins and cytokine production between gammadelta and alphabeta T cells in experimental autoimmune encephalomyelitis. J·Leukoc·Biol. 2008·Jan; 83(1):71‑9. <·PMID:·17928460·>
• Yung R, Powers D, Johnson K, Amento E, Carr D, Laing T, Yang J, Chang S, Hemati N, Richardson B: Mechanisms of drug‑induced lupus (II) T cells overexpressing lymphocyte function‑associated antigen 1 become autoreactive and cause a lupus‑like disease in syngeneic mice. J·Clin·Invest. 1996·Jun·15; 97(12):2866‑71. <·PMID:·8675699·>
Available Safety Data Sheets
CyFlow™ monoclonal antibodies SDS CA EN
Available Technical Data Sheets
CyFlow™ CD11a Low Endotoxin (M17 ' 4) CH435905 TDS (US)