特異性

The mouse monoclonal antibody TRAIL-R4-01 recognizes CD264 (TRAIL-R4) antigen, a 42 kDa transmembrane protein expressed on various blood cells.

抗原情報

CD264 (TRAIL-R4, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumor cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4).

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Clancy L, Mruk K, Archer K, Woelfel M, Mongkolsapaya J, Screaton G, Lenardo MJ, Chan FK: Preligand assembly domain‑mediated ligand‑independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL‑induced apoptosis. Proc·Natl·Acad·Sci·USA. 2005·Dec·13; 102(50):18099‑104. <·PMID:·16319225·>
• Deligezer U, Dalay N: Expression of the TRAIL Receptors in Blood Mononuclear Cells in Leukemia. Pathol·Oncol·Res. 2007; 13(4):290‑4. <·PMID:·18158563·>
• Falschlehner C, Emmerich CH, Gerlach B, Walczak H: TRAIL signalling. Int·J·Biochem·Cell·Biol. 2007; 39(7‑8):1462‑75. <·PMID:·17403612·>
• Mérino D, Lalaoui N, Morizot A, Schneider P, Solary E, Micheau O: Differential inhibition of TRAIL‑mediated DR5‑DISC formation by decoy receptors 1 and 2. Mol·Cell·Biol. 2006·Oct; 26(19):7046‑55. <·PMID:·16980609·>
• Sanlioglu AD, Dirice E, Aydin C, Erin N, Koksoy S, Sanlioglu S: Surface TRAIL decoy receptor‑4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells. BMC·Cancer. 2005·May·25; 5(1):54. <·PMID:·18518976·>