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CyFlow HLA-DR Low Endotoxin

品番 CG154976
抗体名 Anti-Hu HLA-DR LOW END,L243
包装単位 0.1 mg
濃度 1 mg/ml
容量 0.1 ml
関連製品
(アイソタイプコントロール)
Mouse IgG2a Low Endotoxin (AN242943)
反応性|交差吸着 Human | Non-Human Primates | Dog レーザー
抗原 HLA-DR 最大蛍光波長 -
クローン L243 最大励起波長 -
ホスト Mouse 標識/Format Low Endotoxin
アイソタイプ IgG2a 研究分野 MHC
クローナリティ monoclonal 用途

Flow cytometry
Immunoprecipitation
Western blot
Immunohistochemistry
Immunocytochemistry
Functional assays

Anti-Hu HLA-DR LOW END,L243

特異性

The mouse monoclonal antibody L243 recognizes specifically HLA-DR molecules, both peptide-loaded and empty. It is expressed on antigen-presenting cells (dendritic cells, B lymphocytes, monocytes, macrophages).

抗原情報

HLA-DR, a member of MHC class II glycoproteins, that bind intracellularly processed peptides and present them to the Th cells, is composed of 36 kDa α chain and 27 kDa β chain, both anchored in the plasma membrane. Together with other MHC II molecules HLA-DR plays a central role in the immune system.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Bouillon M, El Fakhry Y, Girouard J, Khalil H, Thibodeau J, Mourad W: Lipid raft‑dependent and ‑independent signaling through HLA‑DR molecules. J·Biol·Chem. 2003·Feb·28; 278(9):7099‑107. <·PMID:·12499388·>
• Cantin R, Martin G, Tremblay MJ: A novel virus capture assay reveals a differential acquisition of host HLA‑DR by clinical isolates of human immunodeficiency virus type 1 expanded in primary human cells depending on the nature of producing cells and the donor source. J·Gen·Virol. 2001·Dec; 82(12):2979‑87. <·PMID:·11714974·>
• Coral S, Pucillo C, Leonardi A, Fonsatti E, Altomonte M, Maio M: Triggering of HLA‑DR antigens differentially modulates tumor necrosis factor alpha release by B cells at distinct stage of maturation. Cell·Growth·Differ. 1997·May; 8(5):581‑8. <·PMID:·9149909·>
• De Gassart A, Camosseto V, Thibodeau J, Ceppi M, Catalan N, Pierre P, Gatti E: MHC class II stabilization at the surface of human dendritic cells is the result of maturation‑dependent MARCH I down‑regulation. Proc·Natl·Acad·Sci·USA. 2008·Mar·4; 105(9):3491‑6. <·PMID:·18305173·>
• Ivanov A, Beers SA, Walshe CA, Honeychurch J, Alduaij W, Cox KL, Potter KN, Murray S, Chan CH, Klymenko T, Erenpreisa J, Glennie MJ, Illidge TM, Cragg MS: Monoclonal antibodies directed to CD20 and HLA‑DR can elicit homotypic adhesion followed by lysosome‑mediated cell death in human lymphoma and leukemia cells. J·Clin·Invest. 2009·Aug; 119(8):2143‑59. <·PMID:·19620786·>
• Kalka-Moll WM, Tzianabos AO, Bryant PW, Niemeyer M, Ploegh HL, Kasper DL: Zwitterionic polysaccharides stimulate T cells by MHC class II‑dependent interactions. J·Immunol. 2002·Dec·1; 169(11):6149‑53. <·PMID:·12444118·>
• Muczynski KA, Ekle DM, Coder DM, Anderson SK: Normal human kidney HLA‑DR‑expressing renal microvascular endothelial cells: characterization, isolation, and regulation of MHC class II expression. J·Am·Soc·Nephrol. 2003·May; 14(5):1336‑48. <·PMID:·12707403·>
• Swiatek-de Lange M, Rist W, Stahl HF, Weith A, Lenter MC: Comment on "MHC class II expression identifies functionally distinct human regulatory T cells". J·Immunol. 2008·Mar·15; 180(6):3625. <·PMID:·18322165·>

Available Safety Data Sheets

CyFlow™ monoclonal antibodies SDS CA EN

Available Technical Data Sheets

CyFlow™ HLA-DR Low Endotoxin (L243) CG154976 TDS (US)