特異性

The mouse monoclonal antibody EM-12 recognizes EGFR phosphorylated on tyrosine 992.

抗原情報

The oncoprotein EGFR (epidermal growth factor receptor), also known as HER1 or ErbB1, is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis, although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

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• Rappl A, Piontek G, Schlegel J: EGFR‑dependent migration of glial cells is mediated by reorganisation of N‑cadherin. J·Cell·Sci. 2008·Dec·15; 121(24):4089‑97. <·PMID:·19033391·>
• Yan F, Cao H, Chaturvedi R, Krishna U, Hobbs SS, Dempsey PJ, Peek RM Jr, Cover TL, Washington MK, Wilson KT, Polk DB: Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori‑induced apoptosis. Gastroenterology. 2009·Apr; 136(4):1297‑1307, e1‑3. <·PMID:·19250983·>