CyFlow CD300a Purified
品番 | BX538518 | ||
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抗体名 | Anti-Hu CD300A PURI,MEM-260 | ||
包装単位 | 0.1 mg | ||
濃度 | 1 mg/ml | ||
容量 | 0.1 ml | ||
関連製品 (アイソタイプコントロール) |
Mouse IgG1 Purified (BJ561896) Mouse IgG1 Purified (AS224818) |
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反応性|交差吸着 | Human | レーザー | |
抗原 | CD300a, IRC1, MAIR-I | 最大蛍光波長 | - |
クローン | MEM-260 | 最大励起波長 | - |
ホスト | Mouse | 標識/Format | Purified |
アイソタイプ | IgG1 | 研究分野 | Immunophenotyping |
クローナリティ | monoclonal | 用途 | Flow cytometry |
Anti-Hu CD300A PURI,MEM-260
特異性
The mouse monoclonal antibody MEM-260 recognizes CD300a antigen, a 60 kDa leukocyte transmembrane glycoprotein expressed on human granulocytes, monocytes, neutrophils, NK cells, mast cells and dendritic cells, 25% of circulating T cells and 15% of circulating B cels.
抗原情報
CD300a (CMRF-35H, IRp60) is a non-MHC-specific inhibitory receptor of immunoglobulin superfamily, which contains three immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that associate with SH2-containing phosphatases SHP-1 and SHP-2. CD300a is expressed on many cell types including T cells, NK cells, neutrophils, eosinophils or mast cells. Its triggering inhibits activating signals such as those of IL5, GM-CSF or eotaxin, as well as supresses mast cell degranulation or NK cell cytotoxic activity.
利用方法
保存方法
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
安定性情報
Do not use after expiration date stamped on vial label.
レファレンス
• Alvarez Y, Tang X, Coligan JE, Borrego F: The CD300a (IRp60) inhibitory receptor is rapidly up‑regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signaling. Mol·Immunol. 2008·Jan; 45(1):253‑8. <·PMID:·17588661·>
• Bachelet I, Munitz A, Levi-Schaffer F: Abrogation of allergic reactions by a bispecific antibody fragment linking IgE to CD300a. J·Allergy·Clin·Immunol. 2006·Jun; 117(6):1314‑20. <·PMID:·16750992·>
• Bachelet I, Munitz A, Moretta A, Moretta L, Levi-Schaffer F: The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells. J·Immunol. 2005·Dec·15; 175(12):7989‑95. <·PMID:·16339535·>
• Cantoni C, Bottino C, Augugliaro R, Morelli L, Marcenaro E, Castriconi R, Vitale M, Pende D, Sivori S, Millo R, Biassoni R, Moretta L, Moretta A: Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells. Eur·J·Immunol. 1999·Oct; 29(10):3148‑59. <·PMID:·10540326·>
• Dimasi N, Roessle M, Moran O, Candiano G, Svergun DI, Biassoni R: Molecular analysis and solution structure from small‑angle X‑ray scattering of the human natural killer inhibitory receptor IRp60 (CD300a). Int·J·Biol·Macromol. 2007·Feb·20; 40(3):193‑200. <·PMID:·16949664·>
Available Safety Data Sheets
CyFlow™ monoclonal antibodies SDS CA EN