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CyFlow CD107b Azide Free

品番 BX184646
抗体名 Anti-Hu CD107B AZIDFREE,H4B4
包装単位 0.1 mg
濃度 1 mg/ml
容量 0.1 ml
関連製品
(アイソタイプコントロール)
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反応性|交差吸着 Human レーザー
抗原 CD107b, LAMP-2 最大蛍光波長 -
クローン H4B4 最大励起波長 -
ホスト Mouse 標識/Format Azide Free
アイソタイプ IgG1 研究分野 Immunophenotyping
クローナリティ monoclonal 用途

Flow cytometry
Western blot
Immunohistochemistry
Immunocytochemistry

Anti-Hu CD107B AZIDFREE,H4B4

特異性

The mouse monoclonal antibody H4B4 recognizes CD107b antigen, an extensively glycosylated 100-120 kDa widely expressed lysosome-associated protein.

抗原情報

CD107b (LAMP-2; lysosome-associated membrane protein-2), together with CD107a (LAMP-1), is a major constituent of lysosomal membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes, especially CD107b is important regulator in successful phagosomal maturation. CD107b deficiency causes an accumulation of autophagosomes in many tissues leading to cardiomyopathy and myopathy (Danons disease). Immature CD107b is an approximately 45 kDa protein, but after extensive glycosylation the mature glycoprotein has about 100-120 kDa.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Apte SH, Baz A, Groves P, Kelso A, Kienzle N: Interferon‑gamma and interleukin‑4 reciprocally regulate CD8 expression in CD8+ T cells. Proc·Natl·Acad·Sci·USA. 2008·Nov·11; 105(45):17475‑80. <·PMID:·18988742·>
• Borgne-Sanchez A, Dupont S, Langonné A, Baux L, Lecoeur H, Chauvier D, Lassalle M, Déas O, Briére JJ, Brabant M, Roux P, Péchoux C, Briand JP, Hoebeke J, Deniaud A, Brenner C, Rustin P, Edelman L, Rebouillat D, Jacotot E: Targeted Vpr‑derived peptides reach mitochondria to induce apoptosis of alphaVbeta3‑expressing endothelial cells. Cell·Death·Differ. 2007·Mar; 14(3):422‑35. <·PMID:·16888644·>
• Denzer K, van Eijk M, Kleijmeer MJ, Jakobson E, de Groot C, Geuze HJ: Follicular dendritic cells carry MHC class II‑expressing microvesicles at their surface. J·Immunol. 2000·Aug·1; 165(3):1259‑65. <·PMID:·10903724·>
• Guia S, Cognet C, de Beaucoudrey L, Tessmer MS, Jouanguy E, Berger C, Filipe-Santos O, Feinberg J, Camcioglu Y, Levy J, Al Jumaah S, Al-Hajjar S, Stephan JL, Fieschi C, Abel L, Brossay L, Casanova JL, Vivier E: A role for interleukin‑12/23 in the maturation of human natural killer andCD56+ T cells in vivo. Blood. 2008·May·15; 111(10):5008‑16. <·PMID:·18319400·>
• Kannanganat S, Ibegbu C, Chennareddi L, Robinson HL, Amara RR: Multiple‑cytokine‑producing antiviral CD4 T cells are functionally superior to single‑cytokine‑producing cells. J·Virol. 2007·Aug; 81(16):8468‑76. <·PMID:·17553885·>
• Meade JL, Wilson EB, Holmes TD, de Wynter EA, Brett P, Straszynski L, Ballard PA, Trapani JA, McDermott MF, Cook GP: Proteolytic activation of the cytotoxic phenotype during human NK cell development. J·Immunol. 2009·Jul·15; 183(2):803‑13. <·PMID:·19570824·>
• Palmer DR, Fernandez S, Bisbing J, Peachman KK, Rao M, Barvir D, Gunther V, Burgess T, Kohno Y, Padmanabhan R, Sun W: Restricted replication and lysosomal trafficking of yellow fever 17D vaccine virus in human dendritic cells. J·Gen·Virol. 2007·Jan; 88(1):148‑56. <·PMID:·17170447·>
• Thedrez A, Harly C, Morice A, Salot S, Bonneville M, Scotet E: IL‑21‑mediated potentiation of antitumor cytolytic and proinflammatory responses of human V gamma 9V delta 2 T cells for adoptive immunotherapy. J·Immunol. 2009·Mar·15; 182(6):3423‑31. <·PMID:·19265120·>

Available Safety Data Sheets

CyFlow™ monoclonal antibodies SDS CA EN

Available Technical Data Sheets

CyFlow™ CD107b Azide Free (H4B4) BX184646 TDS (US)