CyFlow CD123 Biotin
| 品番 | BT969077 | ||
|---|---|---|---|
| 抗体名 | Anti-Hu CD123 BIOTIN,6H6 | ||
| 包装単位 | 0.1 mg | ||
| 濃度 | 1 mg/ml | ||
| 容量 | 0.1 ml | ||
| 関連製品 (アイソタイプコントロール) |
Mouse IgG1 Biotin (AQ807476) |
||
| 反応性|交差吸着 | Human | レーザー | |
| 抗原 | CD123, IL-3Ra, IL3R | 最大蛍光波長 | - |
| クローン | 6H6 | 最大励起波長 | - |
| ホスト | Mouse | 標識/Format | Biotin |
| アイソタイプ | IgG1 | 研究分野 | Immunophenotyping | Signaling |
| クローナリティ | monoclonal | 用途 | Flow cytometry |
Anti-Hu CD123 BIOTIN,6H6
特異性
The mouse monoclonal antibody 6H6 recognizes CD123 antigen, a 60-70 kDa transmembrane protein expressed by myeloid precursors, megakaryocytes, macrophages, dendritic cells, mast cells, basophils, and some B cells. This antibody does not inhibit IL-3 binding to its receptor.
抗原情報
CD123 is the α chain of interleukin 3 receptor (IL-3R α). This subunit heterodimerizes with the interleukin 3 receptor β chain (CD131), which is shared with other receptors. CD123 interacts with IL-3 specifically, but with low affinity, and association with the β subunit confers high affinity binding to the receptor heterodimer. Both chains are required for signaling, but receptor activation and signal transduction depend on IL-3 binding to CD123 as the initial step.
利用方法
The reagent is designed for indirect immunofluorescence analysis by Flow Cytometry. Working concentrations should be determined by the investigator.
保存方法
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
安定性情報
Do not use after expiration date stamped on vial label.
レファレンス
• Herling M, Teitell MA, Shen RR, Medeiros LJ, Jones D: TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin. Blood. 2003·Jun·15; 101(12):5007‑9. <·PMID:·12576313·>
• Martín-Gayo E, Sierra-Filardi E, Corbí AL, Toribio ML: Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development. Blood. 2010·Jul·1; 115(26):5366‑75. <·PMID:·20357241·>
• Sun Q, Woodcock JM, Rapoport A, Stomski FC, Korpelainen EI, Bagley CJ, Goodall GJ, Smith WB, Gamble JR, Vadas MA, Lopez AF: Monoclonal antibody 7G3 recognizes the N‑terminal domain of the human interleukin‑3 (IL‑3) receptor alpha‑chain and functions as a specific IL‑3 receptor antagonist. Blood. 1996·Jan·1; 87(1):83‑92. <·PMID:·8547680·>
Available Safety Data Sheets
CyFlow™ monoclonal antibodies SDS CA EN