特異性

The mouse monoclonal antibody UP-H2 recognizes CD300e antigen, a 32 kDa glycoprotein expressed by mature monocytes and peripheral blood myeloid dendritic cells.

抗原情報

CD300e (IREM-2; immune receptor expressed by myeloid cells 2, CLM2 or LMIR6) is a monomeric transmembrane glycoprotein with a single extracellular immunoglobulin-like domain. Intracellularly it associates with DAP-12, an ITAM-containing adaptor molecule. CD300e is expressed on mature monocytes and peripheral blood myeloid dendritic cells. Its crosslinking leads to release of pro-inflammatory cytokines, and increased expression of activation markers.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Aguilar H, Alvarez-Errico D, García-Montero AC, Orfao A, Sayós J, López-Botet M: Molecular characterization of a novel immune receptor restricted to the monocytic lineage. J·Immunol. 2004·Dec·1; 173(11):6703‑11. <·PMID:·15557162·>
• Brckalo T, Calzetti F, Pérez-Cabezas B, Borrás FE, Cassatella MA, López-Botet M: Functional analysis of the CD300e receptor in human monocytes and myeloid dendritic cells. Eur·J·Immunol. 2010·Mar; 40(3):722‑32. <·PMID:·20039296·>
• Clark GJ, Ju X, Tate C, Hart DN: The CD300 family of molecules are evolutionarily significant regulators of leukocyte functions. Trends·Immunol. 2009·May; 30(5):209‑17. <·PMID:·19359216·>