CyFlow CD358 PE
| 品番 | BS736470 | ||
|---|---|---|---|
| 抗体名 | Anti-Hu CD358 PE,DR-6-04-EC | ||
| 包装単位 | 0.1 mg | ||
| 濃度 | 0.1 mg/ml | ||
| 容量 | 1 ml | ||
| 関連製品 (アイソタイプコントロール) |
Mouse IgG1 PE (BV655324) |
||
| 反応性|交差吸着 | Human | レーザー | Blue, Green, Yellow |
| 抗原 | CD358, TNFRSF21, DR6 | 最大蛍光波長 | 576 nm |
| クローン | DR-6-04-EC | 最大励起波長 | 496 nm, 565 nm |
| ホスト | Mouse | 標識/Format | PE |
| アイソタイプ | IgG1 | 研究分野 | Immunophenotyping | Apoptosis |
| クローナリティ | monoclonal | 用途 | Flow cytometry |
Anti-Hu CD358 PE,DR-6-04-EC
特異性
The mouse monoclonal antibody DR-6-04-EC recognizes human CD358 (DR6) antigen, a type I transmembrane protein containing cytoplasmic death domain, widely expressed in most human tissues and cell lines.
抗原情報
CD358 (DR6; Death Receptor-6) is a type I transmembrane protein of the TNF receptor superfamily, expressed in most human tissues and able of inducing apoptosis through its cytoplasmic death domain. Unlike TNFR1 and Fas, DR6 induces apoptosis independently of FADD adaptor. In immune system, DR6 serves as an important regulator for CD4+ T cell proliferation and Th differentiation, and provides also a regulatory mechanism for B cell activation and humoral immune responses.
利用方法
The reagent is designed for Flow Cytometry analysis. Suggested working usage is 10 µg/ml. Indicated dilution is recommended starting point for use of this product, but working concentrations should be validated by the investigator.
保存方法
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
安定性情報
Do not use after expiration date stamped on vial label.
レファレンス
• Kasof GM, Lu JJ, Liu D, Speer B, Mongan KN, Gomes BC, Lorenzi MV: Tumor necrosis factor‑alpha induces the expression of DR6, a member of the TNFreceptor family, through activation of NF‑kappaB. Oncogene. 2001·Nov·29; 20(55):7965‑75. <·PMID:·11753679·>
• Pan G, Bauer JH, Haridas V, Wang S, Liu D, Yu G, Vincenz C, Aggarwal BB, Ni J, Dixit VM: Identification and functional characterization of DR6, a novel deathdomain‑containing TNF receptor. FEBS·Lett. 1998·Jul·24; 431(3):351‑6. <·PMID:·9714541·>
• Rossi D, Gaidano G: Messengers of cell death: apoptotic signaling in health and disease. Haematologica. 2003·Feb; 88(2):212‑8. <·PMID:·12604411·>
• Schmidt CS, Liu J, Zhang T, Song HY, Sandusky G, Mintze K, Benschop RJ, Glasebrook A, Yang DD, Na S: Enhanced B cell expansion, survival, and humoral responses by targeting death receptor 6. J·Exp·Med. 2003·Jan·6; 197(1):51‑62. <·PMID:·12515813·>
Available Safety Data Sheets
CyFlow™ monoclonal antibodies SDS CA EN