特異性

The mouse monoclonal antibody Ki-24 recognizes CD70 antigen, a 50 kDa type II transmembrane glycoprotein expressed on activated lymphocytes and some B cell leukemias.

抗原情報

CD70 (TNFSF7, CD27L) is a 50 kDa type II transmembrane glycoprotein of the TNF superfamily. It is expressed mainly on activated lymphocytes, including NK cells, and forms trimeric structure. CD70 plays a role in T-cell activation, proliferation and differentiation, in enhancing the generation of cytolytic T cells, and in long-term maintenance of T cell memory. It is also involved in B cell differentiation induced by activated plasmacytoid dendritic cells, which also express CD70.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Hashimoto-Okada M, Kitawaki T, Kadowaki N, Iwata S, Morimoto C, Hori T, Uchiyama T: The CD70‑CD27 interaction during the stimulation with dendritic cells promotes naive CD4(+) T cells to develop into T cells producing a broad array of immunostimulatory cytokines in humans. Int·Immunol. 2009·Aug; 21(8):891‑904. <·PMID:·19556308·>
• Israel BF, Pickles RJ, Segal DM, Gerard RD, Kenney SC: Enhancement of adenovirus vector entry into CD70‑positive B‑cell Lines by using a bispecific CD70‑adenovirus fiber antibody. J·Virol. 2001·Jun; 75(11):5215‑21. <·PMID:·11333903·>
• Kaufmann Y, Amariglio N, Rosenthal E, Hirsch YJ, Many A, Rechavi G: Proliferation response of leukemic cells to CD70 ligation oscillates with recurrent remission and relapse in a low‑grade lymphoma. J·Immunol. 2005·Nov·15; 175(10):6940‑7. <·PMID:·16272354·>
• Kaufmann Y, Amariglio N, Rosenthal E, Hirsch YJ, Many A, Rechavi G: Proliferation response of leukemic cells to CD70 ligation oscillates with recurrent remission and relapse in a low‑grade lymphoma. J·Immunol. 2005·Nov·15; 175(10):6940‑7. <·PMID:·16272354·>
• Trebing J, El-Mesery M, Schäfer V, Weisenberger D, Siegmund D, Silence K, Wajant H: CD70‑restricted specific activation of TRAILR1 or TRAILR2 using scFv‑targeted TRAIL mutants. Cell·Death·Dis. 2014·Jan·30; 5:e1035. <·PMID:·24481449·>