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CyFlow CD206 Low Endotoxin

品番 BR421619
抗体名 Anti-Hu CD206 LOW END,15-2
包装単位 0.1 mg
濃度 1 mg/ml
容量 0.1 ml
関連製品
(アイソタイプコントロール)
Mouse IgG1 Low Endotoxin (AK478344)
反応性|交差吸着 Human レーザー
抗原 CD206, MMR 最大蛍光波長 -
クローン 15-2 最大励起波長 -
ホスト Mouse 標識/Format Low Endotoxin
アイソタイプ IgG1 研究分野 Immunophenotyping
クローナリティ monoclonal 用途

Flow cytometry
Immunoprecipitation
Western blot
Immunohistochemistry (frozen sections)
Immunocytochemistry
Functional assays

Anti-Hu CD206 LOW END,15-2

特異性

The mouse monoclonal antibody 15-2 (also known as MR15-2) recognizes CD206 antigen, a 162-175 kDa type I transmembrane protein expressed mainly on macrophages, dendritic cells and hepatic or lymphatic endothelial cells, but not on monocytes.

抗原情報

CD206 (MMR; macrophage mannose receptor or MRC1; mannose receptor C1) is a type I transmembrane glycoprotein serving as pattern recognition receptor for carbogydrate groups on the surface of bacteria, fungi and other pathogens. Expressed mainly on tissue macrophages and dendritic cells, CD206 mediates endocytosis of these pathogens and presentation of their antigens to the adaptive immune system. CD206 can also be detected in a soluble form in human plasma and is elevated in patients with acute sepsis.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Chang YC, Hsu TL, Lin HH, Chio CC, Chiu AW, Chen NJ, Lin CH, Hsieh SL: Modulation of macrophage differentiation and activation by decoy receptor 3. J·Leukoc·Biol. 2004·Mar; 75(3):486‑94. <·PMID:·14657214·>
• Shan M, Klasse PJ, Banerjee K, Dey AK, Iyer SP, Dionisio R, Charles D, Campbell-Gardener L, Olson WC, Sanders RW, Moore JP: HIV‑1 gp120 mannoses induce immunosuppressive responses from dendritic cells. PLoS·Pathog. 2007·Nov; 3(11):e169. <·PMID:·17983270·>
• Sindrilaru A, Peters T, Wieschalka S, Baican C, Baican A, Peter H, Hainzl A, Schatz S, Qi Y, Schlecht A, Weiss JM, Wlaschek M, Sunderkötter C, Scharffetter-Kochanek K: An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice. J·Clin·Invest. 2011·Mar; 121(3):985‑97. <·PMID:·21317534·>
• Sturge J, Todd SK, Kogianni G, McCarthy A, Isacke CM: Mannose receptor regulation of macrophage cell migration. J·Leukoc·Biol. 2007·Sep; 82(3):585‑93. <·PMID:·17596337·>
• Torrelles JB, Azad AK, Schlesinger LS: Fine discrimination in the recognition of individual species of phosphatidyl‑myo‑inositol mannosides from Mycobacterium tuberculosis by C‑type lectin pattern recognition receptors. J·Immunol. 2006·Aug·1; 177(3):1805‑16. <·PMID:·16849491·>
• Mason D, Simmons D, Buckley C, Schwartz-Albiez R, Hadam M, Saalmuller A, Clark E, Malavasi F, Morrissey JA (Eds): Leucocyte Typing VII. Oxford·University·Press. 2002; 1‑945. <·NLM·ID:·101177131·>

Available Safety Data Sheets

CyFlow™ monoclonal antibodies SDS CA EN

Available Technical Data Sheets

CyFlow™ CD206 Low Endotoxin (15-2) BR421619 TDS (US)