CyFlow CD19 Low Endotoxin
品番 | BQ572778 | ||
---|---|---|---|
抗体名 | Anti-Ms CD19 LOW END,1D3 | ||
包装単位 | 0.1 mg | ||
濃度 | 1 mg/ml | ||
容量 | 0.1 ml | ||
関連製品 (アイソタイプコントロール) |
- | ||
反応性|交差吸着 | Mouse | レーザー | |
抗原 | CD19, B4 | 最大蛍光波長 | - |
クローン | 1D3 | 最大励起波長 | - |
ホスト | Rat | 標識/Format | Low Endotoxin |
アイソタイプ | IgG2a | 研究分野 | Immunophenotyping | MHC |
クローナリティ | monoclonal | 用途 | Flow cytometry |
Anti-Ms CD19 LOW END,1D3
特異性
The rat monoclonal antibody 1D3 recognizes mouse CD19 antigen, 95 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on B lymphocytes and follicular dendritic cells; it is lost on plasma cells.
抗原情報
CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.
利用方法
保存方法
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
安定性情報
Do not use after expiration date stamped on vial label.
レファレンス
• Cherukuri A, Cheng PC, Pierce SK: The role of the CD19/CD21 complex in B cell processing and presentation of complement‑tagged antigens. J·Immunol. 2001·Jul·1; 167(1):163‑72. <·PMID:·11418645·>
• Inabe K, Kurosaki T: Tyrosine phosphorylation of B‑cell adaptor for phosphoinositide 3‑kinase is required for Akt activation in response to CD19 engagement. Blood. 2002·Jan·15; 99(2):584‑9. <·PMID:·11781242·>
• Krop I, de Fougerolles AR, Hardy RR, Allison M, Schlissel MS, Fearon DT: Self‑renewal of B‑1 lymphocytes is dependent on CD19. Eur·J·Immunol. 1996·Jan; 26(1):238‑42. <·PMID:·8566073·>
• Krop I, Shaffer AL, Fearon DT, Schlissel MS: The signaling activity of murine CD19 is regulated during cell development. J·Immunol. 1996·Jul·1; 157(1):48‑56. <·PMID:·8683154·>
• Shoham T, Rajapaksa R, Boucheix C, Rubinstein E, Poe JC, Tedder TF, Levy S: The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment. J·Immunol. 2003·Oct·15; 171(8):4062‑72. <·PMID:·14530327·>
Available Safety Data Sheets
CyFlow™ monoclonal antibodies SDS CA EN