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CyFlow CD26 PE

品番 BQ195439
抗体名 Anti-Hu CD26 PE,BA5b
包装単位 100 tests
濃度 -
容量 2 ml
関連製品
(アイソタイプコントロール)
Mouse IgG2a PE (BY503796)
反応性|交差吸着 Human レーザー Blue, Green, Yellow
抗原 CD26, ADABP, DPP4, DDP-4 最大蛍光波長 576 nm
クローン BA5b 最大励起波長 496 nm, 565 nm
ホスト Mouse 標識/Format PE
アイソタイプ IgG2a 研究分野 Immunophenotyping
クローナリティ monoclonal 用途

Flow cytometry

Anti-Hu CD26 PE,BA5b

特異性

The mouse monoclonal antibody BA5b recognizes CD26, a 110 kDa type II membrane glycoprotein, which is a peptidase expressed on mature thymocytes, T cells (especially activated), B cells, NK cells and macrophages.

抗原情報

CD26 (DPP-IV; dipeptidyl peptidase IV) is a homodimeric cell surface serine peptidase that degradates IFN-γ-induced cytokines, acts as a T cell costimulatory molecule, and participates in multiple immunopathological roles in leukocyte homing and inflammation. Alterations in its peptidase activity are characteristic of malignant transformation. The enzymatic activity increases dramatically with tumor grade and severity. CD26 is expressed in various blood cell types, but also e.g. in cells that are histogenetically related to activated fibroblasts. Alterations in CD26 density have been reported on circulating monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.

利用方法

The reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 20 µl reagent / 100 µl of whole blood or 10^6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Dohi O, Ohtani H, Hatori M, Sato E, Hosaka M, Nagura H, Itoi E, Kokubun S: Histogenesis‑specific expression of fibroblast activation proteinand dipeptidylpeptidase‑IV in human bone and soft tissue tumours. Histopathology. 2009·Oct; 55(4):432‑40. <·PMID:·19817894·>
• Doussis IA, Gatter KC, Mason DY: CD68 reactivity of non‑macrophage derived tumours in cytological specimens. J·Clin·Pathol. 1993·Apr; 46(4):334‑6. <·PMID:·7684403·>
• Ellingsen T, Hornung N, Møller BK, Hjelm-Poulsen J, Stengaard-Pedersen K: In active chronic rheumatoid arthritis, dipeptidyl peptidase IV density is increased on monocytes and CD4(+) T lymphocytes. Scand·J·Immunol. 2007·Oct; 66(4):451‑7. <·PMID:·17850590·>
• Kotacková L, Baláziová E, Sedo A: Expression pattern of dipeptidyl peptidase IV activity and/or structure homologues in cancer. Folia·Biol·(Praha). 2009; 55(3):77‑84. <·PMID:·19545486·>
• Stremenova J, Krepela E, Mares V, Trim J, Dbaly V, Marek J, Vanickova Z, Lisa V, Yea C, Sedo A: Expression and enzymatic activity of dipeptidyl peptidase‑IV in human astrocytic tumours are associated with tumour grade. Int·J·Oncol. 2007·Oct; 31(4):785‑92. <·PMID:·17786309·>
• Wong PT, Wong CK, Tam LS, Li EK, Chen DP, Lam CW: Decreased expression of T lymphocyte co‑stimulatory molecule CD26 on invariat natural killer T cells in systemic lupus erythematosus. Immunol·Invest. 2009; 38(5):350‑64. <·PMID:·19811413·>
• Kishimoto T, Goyert S, Kikutani H, Mason D, Miyasaka M, Moretta L, Ohno T, Okumura K, Shaw S, Springer TA, Sugamura K, Sugawara H, von dem Borne AEGK, Zola H (Eds): Leucocyte Typing VI. Garland·Publishing·Inc,·New·York. 1997; 1‑1342. <·NLM·ID:·9712219·>

Available Safety Data Sheets

CyFlow™ monoclonal antibodies SDS CA EN

Available Technical Data Sheets

CyFlow™ CD26 PE (BA5b) BQ195439 TDS (US)