特異性

The mouse monoclonal antibody DR-6-04-EC recognizes human CD358 (DR6) antigen, a type I transmembrane protein containing cytoplasmic death domain, widely expressed in most human tissues and cell lines.

抗原情報

CD358 (DR6; Death Receptor-6) is a type I transmembrane protein of the TNF receptor superfamily, expressed in most human tissues and able of inducing apoptosis through its cytoplasmic death domain. Unlike TNFR1 and Fas, DR6 induces apoptosis independently of FADD adaptor. In immune system, DR6 serves as an important regulator for CD4+ T cell proliferation and Th differentiation, and provides also a regulatory mechanism for B cell activation and humoral immune responses.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Kasof GM, Lu JJ, Liu D, Speer B, Mongan KN, Gomes BC, Lorenzi MV: Tumor necrosis factor‑alpha induces the expression of DR6, a member of the TNFreceptor family, through activation of NF‑kappaB. Oncogene. 2001·Nov·29; 20(55):7965‑75. <·PMID:·11753679·>
• Pan G, Bauer JH, Haridas V, Wang S, Liu D, Yu G, Vincenz C, Aggarwal BB, Ni J, Dixit VM: Identification and functional characterization of DR6, a novel deathdomain‑containing TNF receptor. FEBS·Lett. 1998·Jul·24; 431(3):351‑6. <·PMID:·9714541·>
• Rossi D, Gaidano G: Messengers of cell death: apoptotic signaling in health and disease. Haematologica. 2003·Feb; 88(2):212‑8. <·PMID:·12604411·>
• Schmidt CS, Liu J, Zhang T, Song HY, Sandusky G, Mintze K, Benschop RJ, Glasebrook A, Yang DD, Na S: Enhanced B cell expansion, survival, and humoral responses by targeting death receptor 6. J·Exp·Med. 2003·Jan·6; 197(1):51‑62. <·PMID:·12515813·>