特異性

The rat monoclonal antibody RB6-8C5 recognizes Ly6G component of Gr-1 antigen, a commonly used surface marker of neutrophils.

抗原情報

Ly6G is a component of the myeloid differentiation antigen Gr-1, together with Ly6C. Ly6G is a good marker for detection of peripheral neutrophils. Expression of Gr-1 in bone marrow correlates with granulocyte differentiation and maturation. Physiological role of Ly6G remains still unclear. Its treatment with antibodies in vivo leads to neutropenia and has inhibitory effect on local immune responses.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

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• Leendertse M, Willems RJ, Giebelen IA, Roelofs JJ, Bonten MJ, van der Poll T: Neutrophils are essential for rapid clearance of Enterococcus faecium in mice. Infect·Immun. 2009·Jan; 77(1):485‑91. <·PMID:·19001080·>
• Nagendra S, Schlueter AJ: Absence of cross‑reactivity between murine Ly‑6C and Ly‑6G. Cytometry·A. 2004·Apr; 58(2):195‑200. <·PMID:·15057973·>
• Stoppacciaro A, Melani C, Parenza M, Mastracchio A, Bassi C, Baroni C, Parmiani G, Colombo MP: Regression of an established tumor genetically modified to release granulocyte colony‑stimulating factor requires granulocyte‑T cell cooperation and T cell‑produced interferon gamma. J·Exp·Med. 1993·Jul·1; 178(1):151‑61. <·PMID:·7686211·>