CyFlow DR3 Purified
|抗体名||Anti-Hu DR3 PURI,JD3|
| Mouse IgG1 Purified (BJ561896)
Mouse IgG1 Purified (AS224818)
|アイソタイプ||IgG1||研究分野||Immunophenotyping | Apoptosis|
Anti-Hu DR3 PURI,JD3
The mouse monoclonal antibody JD3 recognizes DR3 antigen, a transmembrane protein of TNFR superfamily expressed mainly in lymphocyte-enriched tissues.
DR3 (APO-3, TRAMP, TNFRSF12) is a death domain-containing receptor of TNFR family, which is expressed preferentially in peripheral blood leukocytes and in the lymphocyte-enriched tissues. Its expression has been shown to be especially up-regulated in activated T cells. DR3 participates e.g. in the removal of self-reactive T cells in the thymus. The ligand for DR3 is TL1A (TNF-like ligand 1A), which is expressed in a variety of cell types (induced by inflammatory stimuli), and can also be released as a soluble factor. The TL1A/DR3 axis has been shown to costimulate T cells to produce a wide variety of cytokines and leads to T cell differentiation towards Th1 and Th17 types.
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
Do not use after expiration date stamped on vial label.
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