特異性

The mouse monoclonal antibody JD3 recognizes DR3 antigen, a transmembrane protein of TNFR superfamily expressed mainly in lymphocyte-enriched tissues.

抗原情報

DR3 (APO-3, TRAMP, TNFRSF12) is a death domain-containing receptor of TNFR family, which is expressed preferentially in peripheral blood leukocytes and in the lymphocyte-enriched tissues. Its expression has been shown to be especially up-regulated in activated T cells. DR3 participates e.g. in the removal of self-reactive T cells in the thymus. The ligand for DR3 is TL1A (TNF-like ligand 1A), which is expressed in a variety of cell types (induced by inflammatory stimuli), and can also be released as a soluble factor. The TL1A/DR3 axis has been shown to costimulate T cells to produce a wide variety of cytokines and leads to T cell differentiation towards Th1 and Th17 types.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Cavallini C, Lovato O, Bertolaso A, Pacelli L, Zoratti E, Zanolin E, Krampera M, ZamòA, Tecchio C, Cassatella MA, Pizzolo G, Scupoli MT: The TNF‑family cytokine TL1A inhibits proliferation of human activated B cells. PLoS·One. 2013; 8(4):e60136. <·PMID:·23565196·>
• Jones GW, Stumhofer JS, Foster T, Twohig JP, Hertzog P, Topley N, Williams AS, Hunter CA, Jenkins BJ, Wang EC, Jones SA: Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. FASEB·J. 2011·Jan; 25(1):409‑19. <·PMID:·20826539·>
• Nakayama M, Ishidoh K, Kayagaki N, Kojima Y, Yamaguchi N, Nakano H, Kominami E, Okumura K, Yagita H: Multiple pathways of TWEAK‑induced cell death. J·Immunol. 2002·Jan·15; 168(2):734‑43. <·PMID:·11777967·>
• Yi B, Zhang M, Schwartz-Albiez R, Cao Y: Mechanisms of the apoptosis induced by CD176 antibody in human leukemic cells. Int·J·Oncol. 2011·Jun; 38(6):1565‑73. <·PMID:·21455576·>