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CyFlow CD103 Purified

品番 BK166852
抗体名 Anti-Hu CD103 PURI,Ber-ACT8
包装単位 0.1 mg
濃度 1 mg/ml
容量 0.1 ml
関連製品
(アイソタイプコントロール)
Mouse IgG1 Purified (BJ561896)
Mouse IgG1 Purified (AS224818)
反応性|交差吸着 Human | Non-Human Primates レーザー
抗原 CD103, ITGAE 最大蛍光波長 -
クローン Ber-ACT8 最大励起波長 -
ホスト Mouse 標識/Format Purified
アイソタイプ IgG1 研究分野 Immunophenotyping
クローナリティ monoclonal 用途

Flow cytometry
Immunoprecipitation
Western blot
Immunohistochemistry (frozen sections)

Anti-Hu CD103 PURI,Ber-ACT8

特異性

The mouse monoclonal antibody Ber-ACT8 recognizes CD103 antigen, a type I transmembrane glycoprotein primarily found on intestinal intraepithelial lymphocytes.

抗原情報

CD103 (Integrin αE) is an integrin subunit that is expressed on intraepithelial lymphocytes, epithelial dendritic cells, lamina propria-derived dendritic cells, a subpopulation of lamina propria T cells, a small subset of peripheral lymphocytes, namely T reg cells, and on activated and TGF-β stimulated lymphocytes. CD103 is in mature form cleaved into two disulfide-linked chains (C-terminal 150 kDa chain and N-terminal 25 kDa chain). It heterodimerizes with integrin β7 subunit to form αE/β7 integrin (mucosal lymphocyte 1 antigen), which through binding E-cadherin mediates homing of lymphocytes to the intestinal epithelium, and, in addition to the role in adhesion, may serve as an accessory molecule for intraepithelial lymphocyte activation.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Brandes M, Willimann K, Lang AB, Nam KH, Jin C, Brenner MB, Morita CT, Moser B: Flexible migration program regulates gamma delta T‑cell involvement in humoral immunity. Blood. 2003·Nov·15; 102(10):3693‑701. <·PMID:·12881309·>
• Cardoso CR, Garlet GP, Moreira AP, Júnior WM, Rossi MA, Silva JS: Characterization of CD4+CD25+ natural regulatory T cells in the inflammatory infiltrate of human chronic periodontitis. J·Leukoc·Biol. 2008·Jul; 84(1):311‑8. <·PMID:·18451325·>
• French JJ, Cresswell J, Wong WK, Seymour K, Charnley RM, Kirby JA: T cell adhesion and cytolysis of pancreatic cancer cells: a role for E‑cadherin in immunotherapy?. Br·J·Cancer. 2002·Oct·21; 87(9):1034‑41. <·PMID:·12434297·>
• Jaensson E, Uronen-Hansson H, Pabst O, Eksteen B, Tian J, Coombes JL, Berg PL, Davidsson T, Powrie F, Johansson-Lindbom B, Agace WW: Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. J·Exp·Med. 2008·Sep·1; 205(9):2139‑49. <·PMID:·18710932·>
• Kost CB, Holden JT, Mann KP: Marginal zone B‑cell lymphoma: a retrospective immunophenotypic analysis. Cytometry·B·Clin·Cytom. 2008·Sep; 74(5):282‑6. <·PMID:·18500740·>
• Kost CB, Holden JT, Mann KP: Marginal zone B‑cell lymphoma: a retrospective immunophenotypic analysis. Cytometry·B·Clin·Cytom. 2008·Sep; 74(5):282‑6. <·PMID:·18500740·>
• León F, Roy G: Isolation of human small bowel intraepithelial lymphocytes by annexin V‑coated magnetic beads. Lab·Invest. 2004·Jun; 84(6):804‑9. <·PMID:·15154017·>
• Poles MA, Barsoum S, Yu W, Yu J, Sun P, Daly J, He T, Mehandru S, Talal A, Markowitz M, Hurley A, Ho D, Zhang L: Human immunodeficiency virus type 1 induces persistent changes in mucosal and blood gammadelta T cells despite suppressive therapy. J·Virol. 2003·Oct; 77(19):10456‑67. <·PMID:·12970431·>
• Sigmundsdottir H, Johnston A, Gudjonsson JE, Bjarnason B, Valdimarsson H: Methotrexate markedly reduces the expression of vascular E‑selectin, cutaneous lymphocyte‑associated antigen and the numbers of mononuclear leucocytes in psoriatic skin. Exp·Dermatol. 2004·Jul; 13(7):426‑34. <·PMID:·15217363·>
• Zhang L, Bertucci AM, Ramsey-Goldman R, Burt RK, Datta SK: Regulatory T cell (Treg) subsets return in patients with refractory lupus following stem cell transplantation, and TGF‑beta‑producing CD8+ Treg cells are associated with immunological remission of lupus. J·Immunol. 2009·Nov·15; 183(10):6346‑58. <·PMID:·19841178·>

Available Safety Data Sheets

CyFlow™ monoclonal antibodies SDS CA EN

Available Technical Data Sheets

CyFlow™ CD103 Purified (Ber-ACT8) BK166852 TDS (US)