CyFlow CD70 PE
| 品番 | BJ865406 | ||
|---|---|---|---|
| 抗体名 | Anti-Hu CD70 PE,Ki-24 | ||
| 包装単位 | 100 tests | ||
| 濃度 | - | ||
| 容量 | 1 ml | ||
| 関連製品 (アイソタイプコントロール) |
- | ||
| 反応性|交差吸着 | Human | レーザー | Blue, Green, Yellow |
| 抗原 | CD70, Ki-24, CD27L, TNFSF7 | 最大蛍光波長 | 576 nm |
| クローン | Ki-24 | 最大励起波長 | 496 nm, 565 nm |
| ホスト | Mouse | 標識/Format | PE |
| アイソタイプ | IgG3 | 研究分野 | Immunophenotyping |
| クローナリティ | monoclonal | 用途 | Flow cytometry |
Anti-Hu CD70 PE,Ki-24
特異性
The mouse monoclonal antibody Ki-24 recognizes CD70 antigen, a 50 kDa type II transmembrane glycoprotein expressed on activated lymphocytes and some B cell leukemias.
抗原情報
CD70 (TNFSF7, CD27L) is a 50 kDa type II transmembrane glycoprotein of the TNF superfamily. It is expressed mainly on activated lymphocytes, including NK cells, and forms trimeric structure. CD70 plays a role in T-cell activation, proliferation and differentiation, in enhancing the generation of cytolytic T cells, and in long-term maintenance of T cell memory. It is also involved in B cell differentiation induced by activated plasmacytoid dendritic cells, which also express CD70.
利用方法
The reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10 µl reagent / 100 µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
保存方法
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
安定性情報
Do not use after expiration date stamped on vial label.
レファレンス
• Hashimoto-Okada M, Kitawaki T, Kadowaki N, Iwata S, Morimoto C, Hori T, Uchiyama T: The CD70‑CD27 interaction during the stimulation with dendritic cells promotes naive CD4(+) T cells to develop into T cells producing a broad array of immunostimulatory cytokines in humans. Int·Immunol. 2009·Aug; 21(8):891‑904. <·PMID:·19556308·>
• Israel BF, Pickles RJ, Segal DM, Gerard RD, Kenney SC: Enhancement of adenovirus vector entry into CD70‑positive B‑cell Lines by using a bispecific CD70‑adenovirus fiber antibody. J·Virol. 2001·Jun; 75(11):5215‑21. <·PMID:·11333903·>
• Kaufmann Y, Amariglio N, Rosenthal E, Hirsch YJ, Many A, Rechavi G: Proliferation response of leukemic cells to CD70 ligation oscillates with recurrent remission and relapse in a low‑grade lymphoma. J·Immunol. 2005·Nov·15; 175(10):6940‑7. <·PMID:·16272354·>
• Kaufmann Y, Amariglio N, Rosenthal E, Hirsch YJ, Many A, Rechavi G: Proliferation response of leukemic cells to CD70 ligation oscillates with recurrent remission and relapse in a low‑grade lymphoma. J·Immunol. 2005·Nov·15; 175(10):6940‑7. <·PMID:·16272354·>
• Trebing J, El-Mesery M, Schäfer V, Weisenberger D, Siegmund D, Silence K, Wajant H: CD70‑restricted specific activation of TRAILR1 or TRAILR2 using scFv‑targeted TRAIL mutants. Cell·Death·Dis. 2014·Jan·30; 5:e1035. <·PMID:·24481449·>
Available Safety Data Sheets
CyFlow™ monoclonal antibodies SDS CA EN