CyFlow CD222 Purified
品番 | BJ078043 | ||
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抗体名 | Anti-Hu CD222 PURI,MEM-238 | ||
包装単位 | 0.1 mg | ||
濃度 | 1 mg/ml | ||
容量 | 0.1 ml | ||
関連製品 (アイソタイプコントロール) |
Mouse IgG1 Purified (BJ561896) Mouse IgG1 Purified (AS224818) |
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反応性|交差吸着 | Human | Non-Human Primates | レーザー | |
抗原 | CD222, IGF2R | 最大蛍光波長 | - |
クローン | MEM-238 | 最大励起波長 | - |
ホスト | Mouse | 標識/Format | Purified |
アイソタイプ | IgG1 | 研究分野 | Immunophenotyping | Signaling |
クローナリティ | monoclonal | 用途 | Flow cytometry |
Anti-Hu CD222 PURI,MEM-238
特異性
The mouse monoclonal antibody MEM-238 recognizes an epitope between domains 2 and 5 of CD222 antigen, a ubiquitously expressed 250 kDa multifunctional type I transmembrane protein. The majority of CD222 is found in the late endosomal/prelysosomal compartment, 5-10% in the plasma membrane and the truncated (220 kDa) form of CD222 is present in human and bovine serum.
抗原情報
CD222 (CIMPR; cation-independent mannose 6-phosphate receptor or IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10% of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-β, last but not least CD222 serves as a receptor for heparanase and even for Listeria.
利用方法
保存方法
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
安定性情報
Do not use after expiration date stamped on vial label.
レファレンス
• Gasanov U, Koina C, Beagley KW, Aitken RJ, Hansbro PM: Identification of the insulin‑like growth factor II receptor as a novel receptor for binding and invasion by Listeria monocytogenes. Infect·Immun. 2006·Jan; 74(1):566‑77. <·PMID:·16369013·>
• Leksa V, Godar S, Cebecauer M, Hilgert I, Breuss J, Weidle UH, Horejsi V, Binder BR, Stockinger H: The N terminus of mannose 6‑phosphate/insulin‑like growth factor 2 receptor in regulation of fibrinolysis and cell migration. J·Biol·Chem. 2002·Oct·25; 277(43):40575‑82. <·PMID:·12189157·>
• Wood RJ, Hulett MD: Cell surface‑expressed cation‑independent mannose 6‑phosphate receptor (CD222 binds enzymatically active heparanase independently of mannose 6‑phosphate to promote extracellular matrix degradation. J·Biol·Chem. 2008·Feb·15; 283(7):4165‑76. <·PMID:·18073203·>
• Mason D, Simmons D, Buckley C, Schwartz-Albiez R, Hadam M, Saalmuller A, Clark E, Malavasi F, Morrissey JA (Eds): Leucocyte Typing VII. Oxford·University·Press. 2002; 1‑945. <·NLM·ID:·101177131·>
Available Safety Data Sheets
CyFlow™ monoclonal antibodies SDS CA EN