CyFlow CD98 Biotin
品番 | BH445832 | ||
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抗体名 | Anti-Hu CD98 BIOTIN,MEM-108 | ||
包装単位 | 0.1 mg | ||
濃度 | 1 mg/ml | ||
容量 | 0.1 ml | ||
関連製品 (アイソタイプコントロール) |
Mouse IgG1 Biotin (AQ807476) |
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反応性|交差吸着 | Human | レーザー | |
抗原 | CD98, 4F2, FRP-1 | 最大蛍光波長 | - |
クローン | MEM-108 | 最大励起波長 | - |
ホスト | Mouse | 標識/Format | Biotin |
アイソタイプ | IgG1 | 研究分野 | Immunophenotyping |
クローナリティ | monoclonal | 用途 | Flow cytometry |
Anti-Hu CD98 BIOTIN,MEM-108
特異性
The mouse monoclonal antibody MEM-108 recognizes CD98 antigen, a 125 kDa disulfide-linked heterodimer (80 kDa glycosylated heavy chain + 45 kDa non-glykosylated light chain). CD98 is expressed on T lymphocytes (upon activation) and activated NK cells; it is also present at low levels on B lymphocytes, NK cells, monocytes and platelets.
抗原情報
CD98 (4F2) is a type II transmembrane glycoprotein which serves as the heavy chain of the heterodimeric amino acid transporters (HATs). CD98, linked to various light chains by disulfide bond, is responsible for cell surface expression and basolateral localization of this transporter complex in polarized epithelial cells and also interacts with β1 integrins and increases their affinity for ligand. Besides its roles in amino acid transport, CD98 is thus involved in cell fusion and activation. It is implicated in regulation of cellular differentiation, growth and apoptosis.
利用方法
The reagent is designed for indirect immunofluorescence analysis by Flow Cytometry. Suggested working usage is 5 µg/ml. Indicated dilution is recommended starting point for use of this product, but working concentrations should be validated by the investigator.
保存方法
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
安定性情報
Do not use after expiration date stamped on vial label.
レファレンス
• Cai S, Bulus N, Fonseca-Siesser PM, Chen D, Hanks SK, Pozzi A, Zent R: CD98 modulates integrin beta1 function in polarized epithelial cells. J·Cell·Sci. 2005·Mar·1; 118(5):889‑99. <·PMID:·15713750·>
• Cho JY, Skubitz KM, Katz DR, Chain BM: CD98‑dependent homotypic aggregation is associated with translocation of protein kinase Cdelta and activation of mitogen‑activated protein kinases. Exp·Cell·Res. 2003·May·15; 286(1):1‑11. <·PMID:·12729789·>
• Dalton P, Christian HC, Redman CW, Sargent IL, Boyd CA: Differential effect of cross‑linking the CD98 heavy chain on fusion and amino acid transport in the human placental trophoblast (BeWo) cell line. Biochim·Biophys·Acta. 2007·Mar; 1768(3):401‑10. <·PMID:·17258169·>
• Liu X, Charrier L, Gewirtz A, Sitaraman S, Merlin D: CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT‑2 in polarized intestinal epithelia. J·Biol·Chem. 2003·Jun·27; 278(26):23672‑7. <·PMID:·12716892·>
• Kishimoto T, Goyert S, Kikutani H, Mason D, Miyasaka M, Moretta L, Ohno T, Okumura K, Shaw S, Springer TA, Sugamura K, Sugawara H, von dem Borne AEGK, Zola H (Eds): Leucocyte Typing VI. Garland·Publishing·Inc,·New·York. 1997; 1‑1342. <·NLM·ID:·9712219·>
Available Safety Data Sheets
CyFlow™ monoclonal antibodies SDS CA EN