研究用フローサイトと理化学分析

世界のリサーチ分野のお客さまへ先端の検査装置のご案内です。

お問い合わせはこちら

sysmex

研究用フローサイトと理化学分析sysmex

CyFlow CD178 Low Endotoxin

品番 BG866777
抗体名 Anti-Hu CD178 LOW END,NOK-1
包装単位 0.1 mg
濃度 1 mg/ml
容量 0.1 ml
関連製品
(アイソタイプコントロール)
Mouse IgG1 Low Endotoxin (AK478344)
反応性|交差吸着 Human レーザー
抗原 CD178, FasL, CD95L, APO1L 最大蛍光波長 -
クローン NOK-1 最大励起波長 -
ホスト Mouse 標識/Format Low Endotoxin
アイソタイプ IgG1 研究分野 Immunophenotyping | Apoptosis
クローナリティ monoclonal 用途

Flow cytometry
Immunoprecipitation
Western blot
Immunocytochemistry
Functional assays

Anti-Hu CD178 LOW END,NOK-1

特異性

The mouse monoclonal antibody NOK-1 recognizes CD178 antigen, a 40 kDa transmembrane glycoprotein expressed on neutrophils, monocytes, and activated T and NK cells.

抗原情報

CD178 (Fas-L; Fas ligand or CD95L), a member of TNF family transmembrane glycoproteins, is responsible for induction of apoptosis in cells containing its receptor Fas/CD95. The CD178-mediated apoptosis pathway has been implicated in peripheral tolerance, tissue pathology, and maintenance of the immune privileged sites. Defects in this interaction may be related to some cases of systemic lupus erythematosus (SLE). CD178 was also described as a co-stimulatory receptor for T-cell activation in mice in vivo.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Chopin D, Barei-Moniri R, Maillé P, Le Frére-Belda MA, Muscatelli-Groux B, Merendino N, Lecerf L, Stoppacciaro A, Velotti F: Human urinary bladder transitional cell carcinomas acquire the functional Fas ligand during tumor progression. Am·J·Pathol. 2003·Apr; 162(4):1139‑49. <·PMID:·12651606·>
• Ghadimi MP, Sanzenbacher R, Thiede B, Wenzel J, Jing Q, Plomann M, Borkhardt A, Kabelitz D, Janssen O: Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178). FEBS·Lett. 2002·May·22; 519(1‑3):50‑8. <·PMID:·12023017·>
• Ji J, Chen JJ, Braciale VL, Cloyd MW: Apoptosis induced in HIV‑1‑exposed, resting CD4+ T cells subsequent to signaling through homing receptors is Fas/Fas ligand‑mediated. J·Leukoc·Biol. 2007·Jan; 81(1):297‑305. <·PMID:·17056762·>
• Jodo S, Pidiyar VJ, Xiao S, Furusaki A, Sharma R, Koike T, Ju ST: Fas ligand (CD178) cytoplasmic tail is a positive regulator of Fas ligand‑mediated cytotoxicity. J·Immunol. 2005·Apr·15; 174(8):4470‑4. <·PMID:·15814666·>
• Kayagaki N, Kawasaki A, Ebata T, Ohmoto H, Ikeda S, Inoue S, Yoshino K, Okumura K, Yagita H: Metalloproteinase‑mediated release of human Fas ligand. J·Exp·Med. 1995·Dec·1; 182(6):1777‑83. <·PMID:·7500022·>

Available Safety Data Sheets

CyFlow™ monoclonal antibodies SDS CA EN

Available Technical Data Sheets

CyFlow™ CD178 Low Endotoxin (NOK-1) BG866777 TDS (US)