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CyFlow CD1c Purified

品番 BG068234
抗体名 Anti-Hu CD1C PURI,L161
包装単位 0.1 mg
濃度 1 mg/ml
容量 0.1 ml
関連製品
(アイソタイプコントロール)
Mouse IgG1 Purified (BJ561896)
Mouse IgG1 Purified (AS224818)
反応性|交差吸着 Human レーザー
抗原 CD1c, R7, CD1 最大蛍光波長 -
クローン L161 最大励起波長 -
ホスト Mouse 標識/Format Purified
アイソタイプ IgG1 研究分野 Immunophenotyping
クローナリティ monoclonal 用途

Flow cytometry
Immunoprecipitation
Immunohistochemistry

Anti-Hu CD1C PURI,L161

特異性

The mouse monoclonal antibody L161 recognizes CD1c antigen, a 43 kDa type I glycoprotein associated with β2-microglobulin. It is expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells, B and some T cells.

抗原情報

CD1c (R7, BDCA1) together with CD1a andCD1b, belongs to group 1 of CD1 antigens. These non-classical MHC-like glycoproteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. The trafficking routes of the particular CD1 types differ and correspond to their ability to bind and present different groups of antigens. CD1c is unique in its ability to present e.g. mycobacterial phosphoketides and polyisoprenoids. CD1c is the only CD1 isoform that has been shown to interact both with α/β and γ/δ T cells.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Briken V, Jackman RM, Watts GF, Rogers RA, Porcelli SA: Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens. J·Exp·Med. 2000·Jul·17; 192(2):281‑8. <·PMID:·10899914·>
• del C Salamone M, Mendiguren AK, Salamone GV, Fainboim L: Membrane trafficking of CD1c on activated T cells. J·Leukoc·Biol. 2001·Oct; 70(4):567‑77. <·PMID:·11590193·>
• Gutzeit C, Raftery MJ, Peiser M, Tischer KB, Ulrich M, Eberhardt M, Stockfleth E, Giese T, Sauerbrei A, Morita CT, Schönrich G: Identification of an important immunological difference between virulent varicella‑zoster virus and its avirulent vaccine: viral disruption of dendritic cellinstruction. J·Immunol. 2010·Jul·1; 185(1):488‑97. <·PMID:·20525895·>
• Scharf L, Li NS, Hawk AJ, Garzón D, Zhang T, Fox LM, Kazen AR, Shah S, Haddadian EJ, Gumperz JE, Saghatelian A, Faraldo-Gómez JD, Meredith SC, Piccirilli JA, Adams EJ: The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation. Immunity. 2010·Dec·14; 33(6):853‑62. <·PMID:·21167756·>
• Todate A, Chida K, Suda T, Imokawa S, Sato J, Ide K, Tsuchiya T, Inui N, Nakamura Y, Asada K, Hayakawa H, Nakamura H: Increased numbers of dendritic cells in the bronchiolar tissues of diffuse panbronchiolitis. Am·J·Respir·Crit·Care·Med. 2000·Jul; 162(1):148‑53. <·PMID:·10903234·>

Available Safety Data Sheets

CyFlow™ monoclonal antibodies SDS CA EN

Available Technical Data Sheets

CyFlow™ CD1c Purified (L161) BG068234 TDS (US)