フローサイトメーター

世界のリサーチ分野のお客さまへ先端の検査装置のご案内です。

  • 神戸:078-992-6272
  • 東京:03-5434-8556

【受付時間09:00~17:35※土日休日を除く/その他休日はサイト上で告知

お問い合わせ

sysmex

フローサイトメーターsysmex

CyFlow CD134 Purified

品番 BF983033
抗体名 Anti-Hu CD134 PURI,Ber-ACT35
包装単位 0.1 mg
濃度 1 mg/ml
容量 0.1 ml
関連製品
(アイソタイプコントロール)
Mouse IgG1 Purified (BJ561896)
Mouse IgG1 Purified (AS224818)
反応性|交差吸着 Human | Non-Human Primates レーザー
抗原 CD134, OX40, TNFRSF4 最大蛍光波長 -
クローン Ber-ACT35 最大励起波長 -
ホスト Mouse 標識/Format Purified
アイソタイプ IgG1 研究分野 Immunophenotyping
クローナリティ monoclonal 用途

Flow cytometry
Immunoprecipitation
Western blot
Immunohistochemistry
ELISA

Anti-Hu CD134 PURI,Ber-ACT35

特異性

The mouse monoclonal antibody Ber-ACT35 (also known as ACT35) recognizes CD134 antigen, a 50 kDa type I transmembrane glycoprotein expressed on activated T cells.

抗原情報

CD134 (TNFRSF4, OX40) is a type I transmembrane glycoprotein of TNF/NGF receptor family expressed on activated T cells, fibroblasts, and hematopoietic precursors. Binding to its ligand (OX40L, TNFSF4) on antigen presenting cells gives to the T cell costimulatory signal, and this interaction results also in B cell proliferation and influences T cell memory pool. CD134 is upregulated at sites of inflammation, especially in case of multiple sclerosis and psoriatic lesions.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Aten J, Roos A, Claessen N, Schilder-Tol EJ, Ten Berge IJ, Weening JJ: Strong and selective glomerular localization of CD134 ligand and TNF receptor‑1 in proliferative lupus nephritis. J·Am·Soc·Nephrol. 2000·Aug; 11(8):1426‑38. <·PMID:·10906156·>
• Endl J, Rosinger S, Schwarz B, Friedrich SO, Rothe G, Karges W, Schlosser M, Eiermann T, Schendel DJ, Boehm BO: Coexpression of CD25 and OX40 (CD134) receptors delineates autoreactive T‑cells in type 1 diabetes. Diabetes. 2006·Jan; 55(1):50‑60. <·PMID:·16380476·>
• Jones D, Fletcher CD, Pulford K, Shahsafaei A, Dorfman DM: The T‑cell activation markers CD30 and OX40/CD134 are expressed in nonoverlapping subsets of peripheral T‑cell lymphoma. Blood. 1999·May·15; 93(10):3487‑93. <·PMID:·10233901·>
• Li M, Zhang Y: The effect of anti‑human CD134 monoclonal antibody on phytohemagglutinin‑induced mRNA expression of perforin in peripheral blood mononuclear cells. Cell·Mol·Immunol. 2005·Dec; 2(6):467‑71. <·PMID:·16426498·>
• Tanijiri T, Shimizu T, Uehira K, Yokoi T, Amuro H, Sugimoto H, Torii Y, Tajima K, Ito T, Amakawa R, Fukuhara S: Hodgkin's reed‑sternberg cell line (KM‑H2) promotes a bidirectional differentiation of CD4+CD25+Foxp3+ T cells and CD4+ cytotoxic T lymphocytes from CD4+ naive T cells. J·Leukoc·Biol. 2007·Sep; 82(3):576‑84. <·PMID:·17545218·>
• Voo KS, Bover L, Harline ML, Vien LT, Facchinetti V, Arima K, Kwak LW, Liu YJ: Antibodies targeting human OX40 expand effector T cells and block inducible and natural regulatory T cell function. J·Immunol. 2013·Oct·1; 191(7):3641‑50. <·PMID:·24014877·>
• Willett BJ, McMonagle EL, Ridha S, Hosie MJ: Differential utilization of CD134 as a functional receptor by diverse strains of feline immunodeficiency virus. J·Virol. 2006·Apr; 80(7):3386‑94. <·PMID:·16537606·>

Available Safety Data Sheets

CyFlow™ monoclonal antibodies SDS CA EN

Available Technical Data Sheets

CyFlow™ CD134 Purified (Ber-ACT35) BF983033 TDS (US)