CyFlow CD177 Purified
品番 | BF539640 | ||
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抗体名 | Anti-Hu CD177 PURI,MEM-166 | ||
包装単位 | 0.1 mg | ||
濃度 | 1 mg/ml | ||
容量 | 0.1 ml | ||
関連製品 (アイソタイプコントロール) |
Mouse IgG1 Purified (BJ561896) Mouse IgG1 Purified (AS224818) |
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反応性|交差吸着 | Human | Non-Human Primates | レーザー | |
抗原 | CD177, NB-1 | 最大蛍光波長 | - |
クローン | MEM-166 | 最大励起波長 | - |
ホスト | Mouse | 標識/Format | Purified |
アイソタイプ | IgG1 | 研究分野 | Immunophenotyping |
クローナリティ | monoclonal | 用途 | Flow cytometry |
Anti-Hu CD177 PURI,MEM-166
特異性
The mouse monoclonal antibody MEM-166 recognizes CD177 antigen, a 60 kDa GPI-linked cell surface glycoprotein of uPAR family, expressed on granulocytes and in bone marrow early erythroblasts, megakaryocytes, promyelocytes and myelocytes.
抗原情報
CD177 (NB1, HNA-2a and PRV-1 form) is a GPI-anchored glycoprotein present mainly on neutrophils. Its plasma membrane expression is increased during pregnancy and and inflammation or after G-CSF application. Ligand of CD177 has been identified as CD31 (PECAM-1). CD177 participates in neutrophil transmigration and seems to be also a pro-proliferative molecule. The antibodies against CD177 can be involved in neonatal alloimmune neutropenia (NAN).
利用方法
保存方法
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
安定性情報
Do not use after expiration date stamped on vial label.
レファレンス
• Bauer S, Abdgawad M, Gunnarsson L, Segelmark M, Tapper H, Hellmark T: Proteinase 3 and CD177 are expressed on the plasma membrane of the same subset of neutrophils. J·Leukoc·Biol. 2007·Feb; 81(2):458‑64. <·PMID:·17077162·>
• Mnjoyan Z, Li J, Afshar-Kharghan V: Expression of polycythemia rubra vera‑1 decreases the dependency of cells on growth factors for proliferation. Haematologica. 2005·Mar; 90(3):405‑6. <·PMID:·15749675·>
• Sachs UJ, Andrei-Selmer CL, Maniar A, Weiss T, Paddock C, Orlova VV, Choi EY, Newman PJ, Preissner KT, Chavakis T, Santoso S: The neutrophil‑specific antigen CD177 is a counter‑receptor for platelet endothelial cell adhesion molecule‑1 (CD31). J·Biol·Chem. 2007·Aug·10; 282(32):23603‑12. <·PMID:·17580308·>
• Stroncek DF, Caruccio L, Bettinotti M: CD177: A member of the Ly‑6 gene superfamily involved with neutrophil proliferation and polycythemia vera. J·Transl·Med. 2004·Mar·29; 2(1):8. <·PMID:·15050027·>
• Kishimoto T, Goyert S, Kikutani H, Mason D, Miyasaka M, Moretta L, Ohno T, Okumura K, Shaw S, Springer TA, Sugamura K, Sugawara H, von dem Borne AEGK, Zola H (Eds): Leucocyte Typing VI. Garland·Publishing·Inc,·New·York. 1997; 1‑1342. <·NLM·ID:·9712219·>
• Mason D, Simmons D, Buckley C, Schwartz-Albiez R, Hadam M, Saalmuller A, Clark E, Malavasi F, Morrissey JA (Eds): Leucocyte Typing VII. Oxford·University·Press. 2002; 1‑945. <·NLM·ID:·101177131·>
Available Safety Data Sheets
CyFlow™ monoclonal antibodies SDS CA EN