CyFlow CD123 PE-Cy7
品番 | BF349525 | ||
---|---|---|---|
抗体名 | Anti-Hu CD123 PE-CY7,6H6 | ||
包装単位 | 100 tests | ||
濃度 | - | ||
容量 | 0.4 ml | ||
関連製品 (アイソタイプコントロール) |
Mouse IgG1 PE-Cy7 (CF148611) |
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反応性|交差吸着 | Human | レーザー | Blue, Green, Yellow |
抗原 | CD123, IL-3Ra, IL3R | 最大蛍光波長 | 785 nm |
クローン | 6H6 | 最大励起波長 | 496 nm, 565 nm |
ホスト | Mouse | 標識/Format | PE-Cy7 |
アイソタイプ | IgG1 | 研究分野 | Immunophenotyping | Signaling |
クローナリティ | monoclonal | 用途 | Flow cytometry |
Anti-Hu CD123 PE-CY7,6H6
特異性
The mouse monoclonal antibody 6H6 recognizes CD123 antigen, a 60-70 kDa transmembrane protein expressed by myeloid precursors, megakaryocytes, macrophages, dendritic cells, mast cells, basophils, and some B cells. This antibody does not inhibit IL-3 binding to its receptor.
抗原情報
CD123 is the α chain of interleukin 3 receptor (IL-3R α). This subunit heterodimerizes with the interleukin 3 receptor β chain (CD131), which is shared with other receptors. CD123 interacts with IL-3 specifically, but with low affinity, and association with the β subunit confers high affinity binding to the receptor heterodimer. Both chains are required for signaling, but receptor activation and signal transduction depend on IL-3 binding to CD123 as the initial step.
利用方法
The reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 4 µl reagent / 100 µl of whole blood or 10^6 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
保存方法
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
安定性情報
Do not use after expiration date stamped on vial label.
レファレンス
• Herling M, Teitell MA, Shen RR, Medeiros LJ, Jones D: TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin. Blood. 2003·Jun·15; 101(12):5007‑9. <·PMID:·12576313·>
• Martín-Gayo E, Sierra-Filardi E, Corbí AL, Toribio ML: Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development. Blood. 2010·Jul·1; 115(26):5366‑75. <·PMID:·20357241·>
• Sun Q, Woodcock JM, Rapoport A, Stomski FC, Korpelainen EI, Bagley CJ, Goodall GJ, Smith WB, Gamble JR, Vadas MA, Lopez AF: Monoclonal antibody 7G3 recognizes the N‑terminal domain of the human interleukin‑3 (IL‑3) receptor alpha‑chain and functions as a specific IL‑3 receptor antagonist. Blood. 1996·Jan·1; 87(1):83‑92. <·PMID:·8547680·>
Available Safety Data Sheets
CyFlow™ monoclonal antibodies SDS CA EN