特異性

The mouse monoclonal antibody V65 recognizes rat TCR γ/δ antigen, the subtype of T cell receptor expressed mainly in epithelial tissues and at the sites of infection.

抗原情報

The antigen-specific T cell receptor (TCR) is composed of either α and β subunit, or γ and δ subunit. Majority of T cells present in the blood, lymph and secondary lymphoid organs express TCR α/β heterodimers, whereas the T cells expressing TCR γ/δ heterodimers are localized mainly in epithelial tissues and at the sites of infection. The subunits of TCR heterodimers are covalently bonded and in the endoplasmic reticulum they associate with CD3 subunits to form functional TCR-CD3 complex. Lack of expression of any of the chains is sufficient to stop cell surface expression.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• De Bernardis F, Lucciarini R, Boccanera M, Amantini C, Arancia S, Morrone S, Mosca M, Cassone A, Santoni G: Phenotypic and functional characterization of vaginal dendritic cells in a rat model of Candida albicans vaginitis. Infect·Immun. 2006·Jul; 74(7):4282‑94. <·PMID:·16790803·>
• Giezeman-Smits KM, Jonges LE, Chambers WH, Brisette-Storkus CS, Van Vlierberghe RL, Van Eendenburg JD, Eggermont AM, Fleuren GJ, Kuppen PJ: Novel monoclonal antibodies against membrane structures that are preferentially expressed on IL‑2‑activated rat NK cells. J·Leukoc·Biol. 1998·Feb; 63(2):209‑15. <·PMID:·9468279·>
• Henriksson G, Helgeland L, Midtvedt T, Stierna P, Brandtzaeg P: Immune response to Mycoplasma pulmonis in nasal mucosa is modulated by the normal microbiota. Am·J·Respir·Cell·Mol·Biol. 2004·Dec; 31(6):657‑62. <·PMID:·15347559·>
• Hosea HJ, Rector ES, Taylor CG: Zinc‑deficient rats have fewer recent thymic emigrant (CD90+) T lymphocytes in spleen and blood. J·Nutr. 2003·Dec; 133(12):4239‑42. <·PMID:·14652378·>
• Moghaddami M, Cleland LG, Mayrhofer G: MHC II+ CD45+ cells from synovium‑rich tissues of normal rats: phenotype, comparison with macrophage and dendritic cell lineages and differentiation into mature dendritic cells in vitro. Int·Immunol. 2005·Aug; 17(8):1103‑15. <·PMID:·16030130·>
• Tam FW, Smith J, Morel D, Karkar AM, Thompson EM, Cook HT, Pusey CD: Development of scarring and renal failure in a rat model of crescentic glomerulonephritis. Nephrol·Dial·Transplant. 1999·Jul; 14(7):1658‑66. <·PMID:·10435873·>
• van den Brandt J, Kwon SH, Hünig T, McPherson KG, Reichardt HM: Sustained pre‑TCR expression in Notch1IC‑transgenic rats impairs T cell maturation and selection. J·Immunol. 2005·Jun·15; 174(12):7845‑52. <·PMID:·15944289·>
• Xystrakis E, Dejean AS, Bernard I, Druet P, Liblau R, Gonzalez-Dunia D, Saoudi A: Identification of a novel natural regulatory CD8 T‑cell subset and analysis of its mechanism of regulation. Blood. 2004·Nov·15; 104(10):3294‑301. <·PMID:·15271801·>