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CyFlow CD146 Purified

品番 AV721526
抗体名 Anti-H/M CD146 PURI,P1H12
包装単位 0.1 mg
濃度 1 mg/ml
容量 0.1 ml
関連製品
(アイソタイプコントロール)
Mouse IgG1 Purified (BJ561896)
Mouse IgG1 Purified (AS224818)
反応性|交差吸着 Human | Mouse | Dog | Rabbit レーザー
抗原 CD146, MCAM 最大蛍光波長 -
クローン P1H12 最大励起波長 -
ホスト Mouse 標識/Format Purified
アイソタイプ IgG1 研究分野 Immunophenotyping
クローナリティ monoclonal 用途

Flow cytometry
Immunoprecipitation
Western blot
Immunohistochemistry
Immunocytochemistry

Anti-H/M CD146 PURI,P1H12

特異性

The mouse monoclonal antibody P1H12 recognizes CD146 antigen, a 118 kDa transmembrane glycoprotein expressed on epithelial and endothelial cells, fibroblasts, multipotent mesenchymal stromal cells, melanoma cells, activated T cells and activated keratinocytes.

抗原情報

CD146 (MCAM; melanoma cell adhesion molecule or MUC18) is a heavily glycosylated transmembrane glycoprotein with more than 50% of the mass from carbohydrates. It is expressed on epithelial and endothelial cells, fibroblasts, multipotent mesenchymal stromal cells, activated T cells and activated keratinocytes, and on some cancer cells, especially melanoma. The presence of CD146 on circulating blood cells has been confined to the activated T cells rather than circulating endothelial cells. CD146 mediates heterophilic cell adhesion and regulates monocyte transendothelial migration.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Finney MR, Greco NJ, Haynesworth SE, Martin JM, Hedrick DP, Swan JZ, Winter DG, Kadereit S, Joseph ME, Fu P, Pompili VJ, Laughlin MJ: Direct comparison of umbilical cord blood versus bone marrow‑derived endothelial precursor cells in mediating neovascularization in response to vascularischemia. Biol·Blood·Marrow·Transplant. 2006·May; 12(5):585‑93. <·PMID:·16635794·>
• Kamstock D, Guth A, Elmslie R, Kurzman I, Liggitt D, Coro L, Fairman J, Dow S: Liposome‑DNA complexes infused intravenously inhibit tumor angiogenesis and elicit antitumor activity in dogs with soft tissue sarcoma. Cancer·Gene·Ther. 2006·Mar; 13(3):306‑17. <·PMID:·16138118·>
• Solovey A, Lin Y, Browne P, Choong S, Wayner E, Hebbel RP: Circulating activated endothelial cells in sickle cell anemia. N·Engl·J·Med. 1997·Nov·27; 337(22):1584‑90. <·PMID:·9371854·>
• Solovey AN, Gui L, Chang L, Enenstein J, Browne PV, Hebbel RP: Identification and functional assessment of endothelial P1H12. J·Lab·Clin·Med. 2001·Nov; 138(5):322‑31. <·PMID:·11709656·>

Available Safety Data Sheets

CyFlow™ monoclonal antibodies SDS CA EN

Available Technical Data Sheets

CyFlow™ CD146 Purified (P1H12) AV721526 TDS (US)